Jan Silhan

Institute of Organic Chemistry and Biochemistry

Czech Republic

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Articles (13)

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2025

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2025

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2024

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2023

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2022

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2022

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2022

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2021

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2021

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2020

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2020

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2020

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2020

Collaborators (3)

Ashley Kamimae-Lanning

University of Oxford

UNITED KINGDOM

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Martin Klima

Institute of Organic Chemistry and Biochemistry

CZECH REPUBLIC

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Anthony O'Donoghue

Associate Professor

University of California, San Diego

UNITED STATES

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Jan Silhan

Research Interests

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Articles (13)

Structural Insights into Salinosporamide a Mediated Inhibition of the Human 20S Proteasome

Mechanistic insights into alcohol-induced DNA crosslink repair by Slx4-Xpf-Ercc1 nuclease complex in the Fanconi anaemia pathway

Structural elucidation of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors

Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase

Model of abasic site DNA cross-link repair; from the architecture of NEIL3 DNA binding domains to the X-structure model

The rate of formation and stability of abasic site interstrand crosslinks in the DNA duplex

Coronaviral RNA-methyltransferases: function, structure and inhibition

Structural Analysis of the OC43 Coronavirus 2′-O-RNA Methyltransferase

High-Throughput Fluorescent Assay for Inhibitor Screening of Proteases from RNA Viruses

Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms.

Structural basis of RNA recognition by the SARS-CoV-2 nucleocapsid phosphoprotein

Conformational changes of DNA repair glycosylase MutM triggered by DNA binding

Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin

Collaborators (3)

Ashley Kamimae-Lanning

Martin Klima

Anthony O'Donoghue

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