Anthony O'Donoghue

Associate Professor

University of California, San Diego

United States

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About

Anthony O'Donoghue is an Associate Professor at UC San Diego, USA. His research areas encompass structural biology and proteomics, with recent articles focusing on the inhibition mechanisms of the human 20S proteasome and the biological activities of marine natural products. He is also involved in studies related to neurobiology and the development of synthetic methodologies for peptide synthesis.

Articles (15)

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2025

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2025

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2024

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2024

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2024

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2022

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2022

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2021

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2020

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2020

Collaborators (8)

William Gerwick

University of California, San Diego

UNITED STATES

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Pavla Fajtová

Institute of Organic Chemistry and Biochemistry

CZECH REPUBLIC

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Jair Siqueira-Neto

Assistant Professor

University of California, San Diego

UNITED STATES

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Jan Silhan

Institute of Organic Chemistry and Biochemistry

CZECH REPUBLIC

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Sydney A. Leibel

University of California, San Diego

UNITED STATES

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Michael Reese

Associate Professor

University of Texas Southwestern Medical Center

UNITED STATES

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Christina D Chambers

Professor

University of California, San Diego

UNITED STATES

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Dean Tantillo

Professor

University of California, Davis

UNITED STATES

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Anthony O'Donoghue

Research Interests

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About

Articles (15)

Structure Elucidation, Biosynthetic Gene Cluster Distribution, and Biological Activities of Ketomemicin Analogs in Salinispora

Structural Insights into Salinosporamide a Mediated Inhibition of the Human 20S Proteasome

Clickable Probes for Pathogen Proteasomes: Synthesis and Applications

Orthogonal Deprotection Strategy of Fmoc Provides Improved Synthesis of Sensitive Peptides: Application to Z-Arg-Lys-AOMK

Structural elucidation of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors

Allergen Content and Protease Activity in Milk Feeds from Mothers of Preterm Infants

Discovery of Triple Inhibitors of Both SARS-CoV-2 Proteases and Human Cathepsin L

Discovery of pH-Selective Marine and Plant Natural Product Inhibitors of Cathepsin B Revealed by Screening at Acidic and Neutral pH Conditions

Dysregulation of Neuropeptide and Tau Peptide Signatures in Human Alzheimer’s Disease Brain

Intramolecular Interactions Enhance the Potency of Gallinamide A Analogues against Trypanosoma cruzi

Molecular Features of CA-074 pH-Dependent Inhibition of Cathepsin B

Differential Neuropeptidomes of Dense Core Secretory Vesicles (DCSV) Produced at Intravesicular and Extracellular pH Conditions by Proteolytic Processing

Activatable Carbocyanine Dimers for Photoacoustic and Fluorescent Detection of Protease Activity

A single-cell RNA-seq atlas of Schistosoma mansoni identifies a key regulator of blood feeding

High-Resolution Mass Spectrometry-Based Approaches for the Detection and Quantification of Peptidase Activity in Plasma

Collaborators (8)

William Gerwick

Pavla Fajtová

Jair Siqueira-Neto

Jan Silhan

Sydney A. Leibel

Michael Reese

Christina D Chambers

Dean Tantillo

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