Janet S. Lee
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Recent Grants
Grant: Close
Host control mechanisms against K. pneumoniae infection in the lungs
Open Date: 2018-04-01
Close Date: 2022-03-31
Grant: Close
Mechanisms of host protection against pathogen-secreted proteases in acute lung injury
Open Date: 2017-08-01
Close Date: 2021-06-30
Grant: Close
Lung Immune Responses and Inflammation in Health and Disease Conference
Open Date: 2016-08-01
Close Date: 2017-07-31
Grant: Close
Enhancing Neutrophil Responses to Counter MDR Gram Negative Bacterial Pneumonia
Open Date: 2015-06-15
Close Date: 2018-05-31
Grant: Close
Cardiolipin as a Novel Mediator of Acute Lung Injury
Open Date: 2014-01-03
Close Date: 2018-12-31
Articles (11)
This study investigates the signaling pathways that mediate induction of BATF2 expression downstream of TLR4 and also the impact of BATF2 on the host defense against pulmonary Kp infection. We demonstrate that Kp-induced upregulation of BATF2 in macrophages requires TRIF and type I IFN signaling. We also show that BATF2 enhances Kp-induced macrophage cytokine responses and that BATF2 contributes to the early host defense against pulmonary Kp infection.
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2023
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Collaborators (6)
Seungchan Kim
Chief Scientist and Executive Professor
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Mounzer Agha
Associate Professor
University of Pittsburgh
Sathish Babu Vasamsetti
Research Assistant Professor
University of Pittsburgh
Wei Chen
University of Pittsburgh
Ling Wang
Research Assistant Professor
The University of Iowa
Ashwin Somasundaram
Assistant Professor of Medicine
University of North Carolina at Chapel Hill
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