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Jannike Nickander

Associate Professor, Resident in Clinical Physiology

Karolinska Institutet
Country flagSweden

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About

Jannike Nickander is an Associate Professor and Resident in Clinical Physiology at Karolinska Institutet in Sweden. Her research focuses on the applications of cardiac imaging, with recent articles addressing topics such as coronary computed tomography angiography in MINOCA, and the implications of myocardial strain in ST-segment elevation myocardial infarction patients. Additionally, her work explores coronary microvascular dysfunction in Takotsubo syndrome and post-acute sequelae of SARS-CoV-2, highlighting her commitment to advancing understanding in cardiovascular health and disease.

Positions (1)

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Jannike Nickander

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Karolinska Institutet

Karolinska Institutet is advertising a postdoctoral position in translational cardiovascular research with a strong focus on cardiovascular magnetic resonance imaging (cardiac MRI / heart-MR) . The project is led by Jannike Nickander in the research group for Clinical Physiology and is centered on understanding and diagnosing coronary microvascular dysfunction in patients without obstructive coronary artery disease. The postdoc will play a central role in planning and coordinating the study, prospectively collecting exercise test data and heart-MR images, analyzing imaging and clinical data, and integrating prior CMR parameters such as quantitative perfusion, scar, and edema. The work also includes processing and integrating data from exercise testing, blood biomarkers, and multi-omics analyses, as well as statistical analysis, interpretation, manuscript writing, and scientific publication. Eligibility highlights: applicants must have a PhD or equivalent degree recognized as comparable to a Swedish doctorate. A doctorate in medicine, biomedicine, physiology, medical engineering, bioinformatics, or a related field is preferred. Strong English skills are required. Because the role involves participant inclusion and clinical examinations, Swedish medical licensure or equivalent is required. Experience in cardiovascular research, cardiac MRI, image analysis, clinical cohort studies, biomarker analysis, statistics, programming, and omics data analysis is highly meritorious. The position is based at Karolinska Institutet in Stockholm, Sweden , with close collaboration between clinical and academic partners and access to a unique patient material from five major hospitals in Stockholm. The appointment is full-time and fixed-term . The application deadline is 2026-05-26 . To apply, use the Varbi recruitment system and submit the required documents: proof of PhD, a complete CV including dissertation date and thesis title, a full publication list, and a one-page summary of current work. Application materials may be written in English or Swedish.

5 months ago

Articles (19)

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2025

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2023

Background. Postacute sequelae of SARS-CoV-2 infection (PASC) are a novel clinical syndrome characterized in part by endothelial dysfunction. Enhanced external counterpulsation (EECP) produces pulsatile shear stress, which has been associated with improvements in systemic endothelial function. Objective. To explore the effects of EECP on symptom burden, physical capacity, mental health, and health-related quality of life (HRQoL) in patients with PASC-associated angina and microvascular dysfunction (MVD). Methods. An interventional pilot study was performed, including 10 patients (male = 5, mean age 50.3 years) recruited from a tertiary specialized PASC clinic. Patients with angina and MVD, defined as index of microcirculatory resistance (IMR) ≥25 and/or diagnosed through stress perfusion cardiac magnetic resonance imaging, were included. Patients underwent one modified EECP course (15 one-hour sessions over five weeks). Symptom burden, six-minute walk test, and validated generic self-reported instruments for measuring psychological distress and HRQoL were assessed before and one month after treatment. Results. At baseline, most commonly reported PASC symptoms were angina (100%), fatigue (80%), and dyspnea (80%). Other symptoms included palpitations (50%), concentration impairment (50%), muscle pain (30%), and brain fog (30%). Mean IMR was 63.6. After EECP, 6MWD increased (mean 29.5 m, median 21 m) and angina and fatigue improved. Mean depression scores showed reduced symptoms (−0.8). Mean HRQoL scores improved in seven out of eight subscales (+0.2 to 10.5). Conclusions. Patients with PASC-associated angina and evidence of MVD experienced subjective and objective benefits from EECP. The treatment was well-tolerated. These findings warrant controlled studies in a larger cohort.

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2023

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2020

Collaborators (6)

Kristina Haugaa

Professor

University of Oslo

NORWAY
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Martin Ugander

Professor

University of Sydney

AUSTRALIA
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Liyew Desta

Karolinska University Hospital

SWEDEN
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Harmony Reynolds

Saul J. Farber Associate Professor of Medicine (Academic)

NYU School of Medicine

UNITED STATES
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Qiaolin Deng

Karolinska Institutet

SWEDEN
View details

Daniel Loewenstein

Karolinska Institutet

SWEDEN
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