Jaroslav Bendl

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Assistant Professor

Icahn School of Medicine at Mount Sinai

United States

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About

Jaroslav Bendl is an Assistant Professor at the Icahn School of Medicine at Mount Sinai, located in the United States. His research focuses on the molecular and cellular mechanisms underlying neurodegenerative diseases, including Alzheimer's disease and major depressive disorder. He has contributed significantly to the fields of single-cell transcriptomics and multiomic profiling, particularly in relation to brain disorders and chromatin accessibility.

Recent Grants

Grant: Close

Epigenetic and transcriptomics mechanisms of Alzheimer’s disease

Open Date: 2021-10-01

Close Date: 2023-09-01

Grant: Close

Unraveling the Mechanism Underlying Bipolar Disorder by Integrated Analysis of Gene Expression, Chromatin Accessibility and Genetic Association Studies

Open Date: 2018-12-01

Close Date: 2021-01-01

Articles (20)

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2022

Collaborators (16)

Wen Zhang

UNITED STATES

Jaroslav Bendl

Research Interests

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About

Recent Grants

Articles (20)

Alzheimer’s disease transcriptional landscape in ex vivo human microglia

Population-scale cross-disorder atlas of the human prefrontal cortex at single-cell resolution

Major-depressive-disorder-associated dysregulation of ZBTB7A in orbitofrontal cortex promotes astrocyte-mediated stress susceptibility

Multiomic single-cell profiling identifies critical regulators of postnatal brain

A multi-regional human brain atlas of chromatin accessibility and gene expression facilitates promoter-isoform resolution genetic fine-mapping

Single cell transcriptomes and multiscale networks from persons with and without Alzheimer’s disease

Genetic regulation of cell type–specific chromatin accessibility shapes brain disease etiology

Single-cell multi-cohort dissection of the schizophrenia transcriptome

Author Correction: Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains

Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains

Genome-wide analysis of a model-derived binge eating disorder phenotype identifies risk loci and implicates iron metabolism

Lineage specific 3D genome structure in the adult human brain and neurodevelopmental changes in the chromatin interactome.

Multi-omic profiling of the developing human cerebral cortex at the single-cell level

Chromatin domain alterations linked to 3D genome organization in a large cohort of schizophrenia and bipolar disorder brains

Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups

The three-dimensional landscape of cortical chromatin accessibility in Alzheimer's disease.

Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome

Population-level variation in enhancer expression identifies disease mechanisms in the human brain

Genetics of the human microglia regulome refines Alzheimer’s disease risk loci

Multi-ancestry eQTL meta-analysis of human brain identifies candidate causal variants for brain-related traits

Collaborators (16)

Wen Zhang

Mark A. Bellgrove

Kristen Brennand

Eunju Im

Thomas D. Als

Ditte Demontis

Kiran Girdhar

Jennifer Phillips-Cremins

Leanne Brown

Anders Rosengren

Georgios Athanasiadis

Søren Dalsgaard

Manuel Mattheisen

Barbara Franke

Joanna Martin

Anita Thapar

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