Jeffrey DeStefano

Professor

University of Maryland

United States

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Jeffrey DeStefano is a Professor at the University of Maryland, USA. His research primarily focuses on the structural biology and biochemical mechanisms of viral processes, particularly regarding HIV and SARS-CoV-2. Recent publications of his include studies on aptamer-based assays, viral polyprotein structures, and the interactions of nucleotides with reverse transcriptases. His work aims to contribute to drug development and enhance our understanding of viral maturation and fidelity in replication.

Articles (11)

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2025

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2023

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2022

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2022

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2022

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2022

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2021

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2021

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2021

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2021

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2021

Collaborators (4)

Nuno Azevedo

University of Porto

PORTUGAL

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Najib El-Sayed

Professor

University of Maryland

UNITED STATES

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Carina Almeida

University of Minho

PORTUGAL

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Eva Pinho

Instituto Nacional de Investigação Agrária e Veterinária

PORTUGAL

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Jeffrey DeStefano

Research Interests

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Articles (11)

A novel aptamer-based dNTP assay reveals that intact HIV virions are highly stable and do not contain enough dNTPs to support DNA synthesis

Inhibition of SARS-CoV-2 infection in human airway epithelium with a xeno-nucleic acid aptamer

Improving aptamer performance with nucleic acid mimics: de novo and post-SELEX approaches

Cryo-EM structure of the HIV-1 Pol polyprotein provides insights into virion maturation

Selection of Primer–Template Sequences That Bind with Enhanced Affinity to Vaccinia Virus E9 DNA Polymerase

Structural basis of HIV inhibition by L-nucleosides: Opportunities for drug development and repurposing

Physiological magnesium concentrations increase fidelity of diverse reverse transcriptases from HIV-1, HIV-2, and foamy virus, but not MuLV or AMV

Xeno-Nucleic Acid (XNA) 2’-Fluoro-Arabino Nucleic Acid (FANA) Aptamers to the Receptor-Binding Domain of SARS-CoV-2 S Protein Block ACE2 Binding

Crystal Structure of a Retroviral Polyprotein: Prototype Foamy Virus Protease-Reverse Transcriptase (PR-RT)

HIV Reverse Transcriptase Pre-Steady-State Kinetic Analysis of Chain Terminators and Translocation Inhibitors Reveals Interactions between Magnesium and Nucleotide 3′-OH

Physiological magnesium concentrations increase fidelity of diverse reverse transcriptases from HIV-1, HIV-2, and foamy virus, but not MuLV or AMV

Collaborators (4)

Nuno Azevedo

Najib El-Sayed

Carina Almeida

Eva Pinho

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