Jeffrey Johnston

Professor

Vanderbilt University

United States

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Jeffrey Johnston is a Professor at Vanderbilt University in the United States. His research focuses on asymmetric catalysis, pharmacology, and peptide chemistry, with recent articles exploring performance-enhancing catalysts, the passive permeability of oligomeric depsipeptides, and structure-activity relationships of antiarrhythmic compounds. His work employs a variety of innovative techniques to elucidate complex chemical interactions and enhance drug development.

Articles (17)

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2025

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2022

Collaborators (3)

Corey Hopkins

Associate Professor

University of Nebraska Medical Center

UNITED STATES

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Nathan Schley

Associate Professor

Vanderbilt University

UNITED STATES

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Bjorn Knollmann

Professor

Vanderbilt University Medical Center

UNITED STATES

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Jeffrey Johnston

Research Interests

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Articles (17)

Performance-Enhancing Asymmetric Catalysis Driven by Achiral Counterion Design

End-to-End Backbone Cyclization Enhances Passive Permeability of bRo5 Oligomeric Depsipeptides with Nonlinear Size Dependence

Elucidating Fluorine Steering Effects in Diels‐Alder Reactions Interfaced with Charge‐Enhanced Reactivity

The backbone constitution drives passive permeability independent of side chains in depsipeptide and peptide macrocycles inspired by ent-verticilide

Backbone-Determined Antiarrhythmic Structure–Activity Relationships for a Mirror Image, Oligomeric Depsipeptide Natural Product

ent-Verticilide B1 Inhibits Type 2 Ryanodine Receptor Channels and is Antiarrhythmic in Casq2 −/− Mice

Generality-Driven Catalyst Development: A Universal Catalyst for Enantioselective Nitroalkene Reduction

In Vivo Pharmacokinetic and Pharmacodynamic Properties of the Antiarrhythmic Moleculeent-Verticilide

The selective RyR2 inhibitor ent-verticilide suppresses atrial fibrillation susceptibility caused by Pitx2 deficiency

Secondary Orbital Effect Involving Fluorine is Responsible for Substrate‐Controlled Diastereodivergence in the Catalyzed syn‐aza‐Henry Reaction of α‐Fluoronitroalkanes

Enantioselective Synthesis of cis- and trans-Cycloheptyl β-Fluoro Amines by Sequential aza-Henry Addition/Ring-Closing Metathesis

Structure–Activity Relationships for the N-Me- Versus N-H-Amide Modification to Macrocyclic ent-Verticilide Antiarrhythmics

Exercise Causes Arrhythmogenic Remodeling of Intracellular Calcium Dynamics in Plakophilin-2–Deficient Hearts

Preparation of N-Aryl Amides by Epimerization-Free Umpolung Amide Synthesis

Resolving Bromonitromethane Sourcing by Synthesis: Preparation at the Decagram Scale

Enantioselective iodolactonization to prepare ε-lactone rings using hypervalent iodine

Fluorine-induced diastereodivergence discovered in an equally rare enantioselective syn-aza-Henry reaction

Collaborators (3)

Corey Hopkins

Nathan Schley

Bjorn Knollmann

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