Bjorn Knollmann

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Vanderbilt University Medical Center

United States

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Professor Bjorn Knollmann is a faculty member at Vanderbilt University Medical Center, located in the United States. His research primarily focuses on cardiac electrophysiology, channelopathies, and the molecular mechanisms underlying arrhythmias. Recent publications have explored therapeutic strategies for disorders such as long QT syndrome and dilated cardiomyopathy, contributing to a deeper understanding of cardiac health and disease.

Recent Grants

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Targeting intracellular calcium leak for ventricular arrhythmia prevention in structural heart disease

Open Date: 2019-07-01

Close Date: 2023-06-30

Grant: Close

The mechanistic role of RyR2 hyperactivity for ventricular arrhythmia in animal models of structural heart disease

Open Date: 2019-07-01

Close Date: 2023-06-30

Grant: Close

Toward a Mechanism-Based Approach to Treating Atrial Fibrillation

Open Date: 2015-05-15

Close Date: 2019-03-31

Grant: Close

Pannexin channels in cardiac arrhythmias

Open Date: 2015-04-01

Close Date: 2019-03-31

Grant: Close

Flecainide for Catecholaminergic Polymorphic Ventricular Tachycardia

Open Date: 2011-06-20

Close Date: 2016-03-31

Articles (16)

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2025

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2022

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2022

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2022

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2022

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2022

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2021

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2020

Collaborators (10)

Alexey Glukhov

Imperial College London

UNITED KINGDOM

Assistant Professor

Vanderbilt University

UNITED STATES

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Bjorn Knollmann

Research Interests

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About

Recent Grants

Articles (16)

High throughput screens identify genotype-specific therapeutics for channelopathies

Finding the right balance of RyR2 phosphorylation for arrhythmia prevention

Cardiac Troponin C E135A Variant Impairs Myofilament Response to PKA Phosphorylation and Is Associated With Autosomal Dominant Dilated Cardiomyopathy With Diastolic Dysfunction

The proteostasis interactomes of trafficking-deficient variants of the voltage-gated potassium channel KV11.1 associated with long QT syndrome

The backbone constitution drives passive permeability independent of side chains in depsipeptide and peptide macrocycles inspired by ent-verticilide

Ryanodine receptor inhibition with acute dantrolene treatment reduces arrhythmia susceptibility in human hearts

Danicamtiv Recruits Myosin Motors to Aid the Failing Heart

In Vivo Pharmacokinetic and Pharmacodynamic Properties of the Antiarrhythmic Moleculeent-Verticilide

Studying Long QT Syndrome Caused by NAA10 Genetic Variants Using Patient-Derived Induced Pluripotent Stem Cells

Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals.

SR-Mitochondria Crosstalk Shapes Ca Signalling to Impact Pathophenotype in Disease Models Marked by Dysregulated Intracellular Ca Release

Impaired Dynamic Sarcoplasmic Reticulum Ca Buffering in Autosomal Dominant CPVT2

Animal Models to Study Cardiac Arrhythmias

Exercise Causes Arrhythmogenic Remodeling of Intracellular Calcium Dynamics in Plakophilin-2–Deficient Hearts

RYR2 Channel Inhibition Is the Principal Mechanism of Flecainide Action in CPVT

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Collaborators (10)

Alexey Glukhov

Nikki Gillum Posnack

Sharon George

Na Li

Robert Rose

Steven Poelzing

Igor Efimov

Dmytro Kryshtal

Jeffrey Johnston

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