Jessica Fortin

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Assistant Professor (Tenure-track)

College of Veterinary Medicine, Purdue University

United States

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Jessica Fortin is an Assistant Professor (Tenure-track) at the College of Veterinary Medicine, Purdue University, USA. Her research focuses on neurodegenerative diseases, particularly the aggregation of proteins such as α-synuclein and tau, and the development of therapeutic agents. Recent articles include evaluations of small molecule inhibitors and the classification of amyloidosis in animals.

Recent Grants

Grant: Open

Small molecule inhibitors of hyperphosphorylated tau aggregation in Alzheimer's disease: lead optimization, and proof of concept in a rodent model

Open Date: 2022-05-15

Close Date: 2027-04-30

Grant: Close

Small molecule inhibitors of hyperphosphorylated tau aggregation and cytotoxicity for the development of Alzheimer’s therapeutics

Open Date: 2021-09-15

Close Date: 2023-05-31

Grant: Close

Interaction de la protéine MRP4 avec les flavonoïdes d origine alimentaire et le glutathion.

Open Date: 2008-04-01

Close Date: 2010-03-31

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2021

Collaborators (6)

Tomoaki Murakami

Associate Professor

Tokyo University of Agriculture and Technology

JAPAN

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Ulf Dettmer

Assistant Professor of Neurology

Brigham and Women's Hospital

UNITED STATES

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Harold C. Schott

UNITED STATES

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Dongsheng Duan

Professor

University of Missouri Columbia

UNITED STATES

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George Perry

Professor

University of Texas at San Antonio

UNITED STATES

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Susantha K. Ganegamage

Assistant Professor

Lamar University

UNITED STATES

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Jessica Fortin

Research Interests

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About

Recent Grants

Articles (20)

Classification of amyloidosis and protein misfolding disorders in animals 2024: A review on pathology and diagnosis

Inspecting the Triazole Scaffold as Powerful Antifibril Agents against 2N4R Tau and α-Synuclein Aggregates

In Vitro Evaluation of Amide-Linked Coumarin Scaffolds for the Inhibition of α-Synuclein and Tau Aggregation

Utilizing image analysis by optical density to evaluate changes in hematoxylin and eosin staining quality after reagent overuse

The aggregation tendencies of the signal peptide regions of prone and not prone to aggregate proteins

Updates on Tau-Related Drug Targets and Potential Disease-Modifying Therapies for Alzheimer’s Disease

Evaluation of Alpha-Synuclein and Tau Antiaggregation Activity of Urea and Thiourea-Based Small Molecules for Neurodegenerative Disease Therapeutics

Exploring the rhodanine universe: Design and synthesis of fluorescent rhodanine-based derivatives as anti-fibrillar and anti-oligomer agents against α-synuclein and 2N4R tau

Understanding alpha-synuclein aggregation propensity in animals and humans

Discovery of small molecule benzothiazole and indole derivatives tackling tau 2N4R and α-synuclein fibrils

Discovery of 4-aminoindole carboxamide derivatives to curtail alpha-synuclein and tau isoform 2N4R oligomer formation

Hyperphosphorylated tau (p-tau) and drug discovery in the context of Alzheimer's disease and related tauopathies

Recent Advances in the Discovery of Therapeutics to Curtail Islet Amyloid Polypeptide Aggregation for Type 2 Diabetes Treatment.

Anti-fibrillization effects of sulfonamide derivatives on <i>α</i>-synuclein and hyperphosphorylated tau isoform 1N4R.

Revisiting misfolding propensity of serum amyloid A1: Special focus on the signal peptide region.

A novel chemical marker of tremorgenic mycotoxicosis detected by gas-chromatography/mass-spectrometry

In vitro characterization of urea derivatives to inhibit alpha-synuclein early-stage aggregation

Equine pituitary pars intermedia dysfunction: a spontaneous model of synucleinopathy.

Survey of amyloidosis cases among different free-living wild and zoo animals.

Widespread severe myodegeneration in a compound heterozygote female dog with dystrophin deficiency.

Collaborators (6)

Tomoaki Murakami

Ulf Dettmer

Harold C. Schott

Dongsheng Duan

George Perry

Susantha K. Ganegamage

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