Ulf Dettmer

Assistant Professor of Neurology

Brigham and Women's Hospital

United States

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Articles (17)

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2024

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2020

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2020

Collaborators (6)

Lei Liu

Assistant Professor of Neurology

Harvard Medical School

UNITED STATES

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Gary Ho

Assistant Professor

Harvard Medical School

UNITED STATES

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Jessica Fortin

Assistant Professor (Tenure-track)

College of Veterinary Medicine, Purdue University

UNITED STATES

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Susantha K. Ganegamage

Assistant Professor

Lamar University

UNITED STATES

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Dennis J. Selkoe

Vincent and Stella Coates Professor of Neurologic Diseases

Harvard Medical School

UNITED STATES

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Guy Caldwell

University Distinguished Research Professor

The University of Alabama

UNITED STATES

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Ulf Dettmer

Research Interests

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Articles (17)

Physiological roles of α-synuclein serine-129 phosphorylation – not an oxymoron

A stem cell-based assay platform demonstrates alpha-synuclein dependent synaptic dysfunction in patient-derived cortical neurons

Author Correction: Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson’s disease phenotypes

Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson’s disease phenotypes

Adding hydrophobicity or positive charges to the cytosolic half of the α‐synuclein 3–11 helix increases membrane association and S129 phosphorylation

Discovery of 4-aminoindole carboxamide derivatives to curtail alpha-synuclein and tau isoform 2N4R oligomer formation

The effects of KTKEGV repeat motif and intervening ATVA sequence on α‐synuclein solubility and assembly

Dynamic reversibility of α‐synuclein serine‐129 phosphorylation is impaired in synucleinopathy models

Astrocytes in Parkinson’s Disease: From Role to Possible Intervention

Lipase regulation of cellular fatty acid homeostasis as a Parkinson’s disease therapeutic strategy

Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous α-synuclein in human neurons

Lipotoxicity Downstream of α-Synuclein Imbalance: A Relevant Pathomechanism in Synucleinopathies?

Wild-type GBA1 increases the α-synuclein tetramer–monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice

Temperature is a key determinant of alpha- and beta-synuclein membrane interactions in neurons

A stearoyl-CoA desaturase inhibitor prevents multiple Parkinson's disease-phenotypes in α-synuclein mice.

Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor

Vesicle trafficking and lipid metabolism in synucleinopathy.

Collaborators (6)

Lei Liu

Gary Ho

Jessica Fortin

Susantha K. Ganegamage

Dennis J. Selkoe

Guy Caldwell

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