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Ulf Dettmer

Assistant Professor of Neurology

Brigham and Women's Hospital

United States

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Research Interests

Neurology

30%

Biochemistry

70%

Neurodegenerative Disease

80%

Parkinson's Disease

60%

Prion Biology

50%

Neurochemistry

50%

Proteostasis

50%

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Articles17

Physiological roles of α-synuclein serine-129 phosphorylation – not an oxymoron

Article Link

Year:

2024

A stem cell-based assay platform demonstrates alpha-synuclein dependent synaptic dysfunction in patient-derived cortical neurons

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Year:

2024

Author Correction: Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson’s disease phenotypes

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Year:

2024

Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson’s disease phenotypes

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Year:

2024

Adding hydrophobicity or positive charges to the cytosolic half of the α‐synuclein 3–11 helix increases membrane association and S129 phosphorylation

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Year:

2024

Discovery of 4-aminoindole carboxamide derivatives to curtail alpha-synuclein and tau isoform 2N4R oligomer formation

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Year:

2023

The effects of KTKEGV repeat motif and intervening ATVA sequence on α‐synuclein solubility and assembly

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Year:

2023

Dynamic reversibility of α‐synuclein serine‐129 phosphorylation is impaired in synucleinopathy models

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Year:

2023

Astrocytes in Parkinson’s Disease: From Role to Possible Intervention

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Year:

2023

Lipase regulation of cellular fatty acid homeostasis as a Parkinson’s disease therapeutic strategy

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Year:

2022

Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous α-synuclein in human neurons

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Year:

2022

Lipotoxicity Downstream of α-Synuclein Imbalance: A Relevant Pathomechanism in Synucleinopathies?

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Year:

2021

Wild-type GBA1 increases the α-synuclein tetramer–monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice

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Year:

2021

Temperature is a key determinant of alpha- and beta-synuclein membrane interactions in neurons

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Year:

2021

A stearoyl-CoA desaturase inhibitor prevents multiple Parkinson's disease-phenotypes in α-synuclein mice.

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Year:

2020

Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor

Article Link

Year:

2020

Vesicle trafficking and lipid metabolism in synucleinopathy.

Article Link

Year:

2020

Collaborators6

Lei Liu

Assistant Professor of Neurology

Harvard Medical School

UNITED STATES

Gary Ho

Assistant Professor

Harvard Medical School

UNITED STATES

Jessica Fortin

Assistant Professor (Tenure-track)

College of Veterinary Medicine, Purdue University

UNITED STATES

Susantha K. Ganegamage

Assistant Professor

Lamar University

UNITED STATES

Dennis J. Selkoe

Vincent and Stella Coates Professor of Neurologic Diseases

Harvard Medical School

UNITED STATES

Guy Caldwell

University Distinguished Research Professor

The University of Alabama

UNITED STATES

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