Jiajie Diao

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Assistant Professor/Associate Professor

University of Cincinnati College of Medicine

United States

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About

Dr. Jiajie Diao is an Assistant Professor at the University of Cincinnati College of Medicine in the United States. His research areas include microscopy techniques for organelle dynamics, optogenetic engineering, and the molecular mechanisms related to synucleinopathies and autophagosome-lysosome fusion. He is actively involved in developing innovative fluorescent probes for bioimaging and studying the biochemical effects of lipid droplets in cancer biology.

Recent Grants

Grant: Close

The role of VAMP2 in alpha-synuclein function and pathology

Open Date: 2021-04-01

Close Date: 2026-04-01

Grant: Close

Single-molecule study of alpha-synuclein

Open Date: 2019-09-01

Close Date: 2021-07-01

Grant: Close

Chaperones of alpha-synuclein for membrane fusion involved in synaptic transmission

Open Date: 2019-03-01

Close Date: 2020-08-01

Grant: Close

SNARE-mediated membrane fusion involved in autophagosome biogenesis

Open Date: 2018-08-01

Close Date: 2023-08-01

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2022

Collaborators (12)

Junichi Usuba

Designated Assistant Professor

JAPAN

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Assistant Professor

The University of Alabama at Birmingham School of Medicine

UNITED STATES

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Jiajie Diao

Research Interests

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About

Recent Grants

Articles (29)

A Versatile Near‐Infrared Fluorescent Probe for Fast Assessment of Lysosomal Status via a Large Multimodal Model

Seeing the Unseen: Structured Illumination Microscopy for Organelles Dynamics

Optogenetic engineering of lipid droplet spatial organization for tumor suppression

Clustered Carbon Nanotubes Damage Endoplasmic Reticulum

α-Synuclein condensation in synaptic vesicle function and synucleinopathies

Molecular structures and function of the autophagosome-lysosome fusion machinery

Cell-free nonequilibrium assembly for hierarchical protein/peptide nanopillars

Super-resolution imaging of sub-cellular dynamics of drug molecules

Monitoring Escherichia coli in Water through Real-Time Loop-Mediated Isothermal Amplification on Biochips

Sustainable synthesis of carbon dots via bio‐waste recycling for biomedical imaging

VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates.

A matter of timing

Lysophosphatidylcholine binds α-synuclein and prevents its pathological aggregation.

Q&A with Jiajie Diao.

METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation.

N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine

Duplex Unwinding Mechanism of Coronavirus MERS-CoV nsp13 Helicase

Recent advances in single fluorescent probes for monitoring dual organelles in two channels

Near-Infrared Bioimaging Using Two-photon Fluorescent Probes.

A general design of pyridinium-based fluorescent probes for enhancing two-photon microscopy.

Programmable Digital-Microfluidic Biochips for SARS-CoV-2 Detection

Advanced imaging techniques for tracking drug dynamics at the subcellular level

Graphene Oxide Nanosheets Induce Mitochondrial Fragmentation by Cutting through Membrane

Monitoring lysosomal acidity

Constant Conversion Rate of Endolysosomes Revealed by a pH-Sensitive Fluorescent Probe

Double-transmembrane domain of SNAREs decelerates the fusion by increasing the protein-lipid mismatch.

2D MoS<sub>2</sub> and BN Nanosheets Damage Mitochondria through Membrane Penetration.

Quantifying cell viability through organelle ratiometric probing

Inhibition of Amyloid Nucleation by Steric Hindrance

Collaborators (12)

Junichi Usuba

Yuxin Wang

Minling Zhong

Michael Hagan

Rui Chen

Bidyut Kumar Kundu

Kai Zhang

Christopher Elles

Calvin Yip

Yujie Sun

Ziyuan Guo

Fengbin Wang

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