Jian Liu

Professor

University of North Carolina at Chapel Hill

United States

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About

Jian Liu is a Professor at the University of North Carolina at Chapel Hill, USA. His research focuses on heparan sulfate and its interactions with proteins, alongside the development of analytical methods for studying glycosaminoglycans. Recent articles highlight his work on synthetic structures impairing synaptic function and microbial interactions in periodontal disease.

Articles (16)

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2025

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University of North Carolina at Chapel Hill

UNITED STATES

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Jian Liu

Research Interests

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About

Articles (16)

A synthetic HS structure selectively impairs the morphology and function of excitatory synapse by disrupting neurexin1 interactions

Utilizing 13C-Labeled internal standards to advance the analysis of heparan sulfate

Editor’s Choice Development of a method to measure the activity of heparan sulfate 6-endosulfatase for biological research

Utility of Authentic 13C‐Labeled Disaccharide to Calibrate Hyaluronan Content Measurements by LC‐MS

Modeling interactions between Heparan sulfate and proteins based on the Heparan sulfate microarray analysis

Structural and Functional Analysis of Heparosan Synthase 2 from Pasteurella multocida to Improve the Synthesis of Heparin

Microbial β-glucuronidases drive human periodontal disease etiology

Emerging chemical and biochemical tools for studying 3-O-sulfated heparan sulfate

Correction to Analysis of 3-O-Sulfated Heparan Sulfate Using Isotopically Labeled Oligosaccharide Calibrants

Analysis of 3-O-Sulfated Heparan Sulfate Using Isotopically Labeled Oligosaccharide Calibrants

Structural and Substrate Specificity Analysis of 3-O-Sulfotransferase Isoform 5 to Synthesize Heparan Sulfate

Synthesis of 3-O-Sulfated Heparan Sulfate Oligosaccharides Using 3-O-Sulfotransferase Isoform 4

Improving the Sensitivity for Quantifying Heparan Sulfate from Biological Samples

Deciphering the substrate recognition mechanisms of the heparan sulfate 3-O-sulfotransferase-3

Investigation of the biological functions of heparan sulfate using a chemoenzymatic synthetic approach

Potential Use of Anti-Inflammatory Synthetic Heparan Sulfate to Attenuate Liver Damage

Collaborators (5)

Lars Pedersen

Chunyu Wang

Adam Lietzan

Peng Zhang

Matthew Redinbo

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