Chunyu Wang

Professor

Rensselaer Polytechnic Institute

United States

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About

Chunyu Wang is a Professor at Rensselaer Polytechnic Institute, United States. His research areas focus on cancer biology, particularly the role of Hedgehog signaling in cancer drug discovery, and the structural biology of various protein interactions. He has published on topics such as neoepitopes in pancreatic adenocarcinoma, molecular dynamics simulations of heparin, and the effects of compounds on β-amyloid peptides related to Alzheimer's Disease.

Articles (13)

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2025

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2025

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2023

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2022

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2022

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2022

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2021

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2021

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2020

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2020

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2020

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University at Buffalo

UNITED STATES

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Chunyu Wang

Research Interests

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Articles (13)

Conserved C143 forms a branched intermediate in Hedgehog autoprocessing: A cancer drug discovery target against Hedgehog signaling

Comparison of Shared Class I HLA-Bound Noncanonical Neoepitopes between Normal and Neoplastic Tissues of Pancreatic Adenocarcinoma

A Structural Model for the Core Nup358-BicD2 Interface

Coil-to-α-helix transition at the Nup358-BicD2 interface activates BicD2 for dynein recruitment

Nanomolar, Noncovalent Antagonism of Hedgehog Cholesterolysis: Exception to the “Irreversibility Rule” for Protein Autoprocessing Inhibition

Characterization of Heparin’s Conformational Ensemble by Molecular Dynamics Simulations and Nuclear Magnetic Resonance Spectroscopy

Synthesis of 3-O-Sulfated Heparan Sulfate Oligosaccharides Using 3-O-Sulfotransferase Isoform 4

pH-dependent and dynamic interactions of cystatin C with heparan sulfate

Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis

In Vitro Effects of (+)MK-801 (dizocilpine) and Memantine on β-Amyloid Peptides Linked to Alzheimer’s Disease

Allosteric Influence of Extremophile Hairpin Motif Mutations on the Protein Splicing Activity of a Hyperthermophilic Intein

3-O-Sulfation of Heparan Sulfate Enhances Tau Interaction and Cellular Uptake

Substrate interaction inhibits γ-secretase production of amyloid-β peptides

Collaborators (7)

Erik Debler

M. Yusuf ALi

Brian Callahan

Jian Liu

Sozanne R Solmaz

Nathan Smith

Ding Xu

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