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Jianxiong Jiang

Professor

University of Tennessee Health Science Center

United States

Research Interests

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Articles (26)

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Collaborators (7)

Frank Park

Associate Professor

University of Tennessee Health Science Center

UNITED STATES

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Kelli Adeleye

University of Tennessee Health Science Center

UNITED STATES

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Chao-Yie Yang

Associate Professor

University of Tennessee Health Science Center

UNITED STATES

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Najah Albadari

Head of Pharmaceutical Chemistry Department

university of ha’il

SAUDI ARABIA

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Yang Xie

UNITED STATES

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Bernd Meibohm

UNITED STATES

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Wei Li

UTHSC Distinguished Professor and Director of UTCoP Drug Discovery Center

University of Tennessee Health Science Center

UNITED STATES

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Jianxiong Jiang

Research Interests

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Articles (26)

QW-5-70 Targets the Colchicine Site and Demonstrates Antitumor Activity in P-gp–Overexpressing Cancer Models

Highly potent, brain‐penetrant EP2 receptor antagonists for the treatment of permanent focal cerebral ischaemia in male and female mice

Centanafadine (Simtriyo): a triple monoamine reuptake inhibitor for ADHD

Identifying targets at the blood-brain barrier for treating vascular cognitive impairment and dementia

Topical difamilast for the treatment of mild-to-moderate atopic dermatitis

Zycubo (copper histidinate), the first treatment for pediatric Menkes disease

An inhibitor of UHM splicing factors exerts anti-leukemic activity by altering cell cycle progression and reducing lysosome acidification

Siglec-E deletion alters AT macrophages phenotypes, induces an inflammatory response, and adipogenesis during diet-induced obesity.

Targeting NLRP3 signaling with a novel sulfonylurea compound for the treatment of vascular cognitive impairment and dementia.

Discovery of Highly Potent Naphthalene/Quinoline-Based PAD Inhibitors: Structure-Activity Relationship, Selectivity, and Cytotoxicity

Modulating inflammatory prostaglandin E2 signaling to mitigate neurobehavioral comorbidities associated with seizure disorders

New structural scaffolds to enhance the metabolic stability of arginine-derived PAD4 inhibitors

Suzetrigine for moderate to severe acute pain

Siglec-E augments adipose tissue inflammation by modulating TRAF3 signaling and monocytic myeloid-derived suppressor cells during obesity.

Pathophysiological significance and modulation of the transient receptor potential canonical 3 ion channel

Eflornithine for treatment of high-risk neuroblastoma

JW-1-283 inhibits melanoma tumor growth via stabilization of the p53 pathway

Complementary roles of EP2 and EP4 receptors in malignant glioma

The inducible prostaglandin E synthase (mPGES-1) in neuroinflammatory disorders

Neuroinflammatory mediators in acquired epilepsy: an update

The discovery of cyclic γ-AApeptides as the promising ligands targeting EP2.

Novel, Brain-Permeable, Cross-Species Benzothiazole Inhibitors of Microsomal Prostaglandin E Synthase-1 (mPGES-1) Dampen Neuroinflammation <i>In Vitro</i> and <i>In Vivo</i>.

Pharmacologically targeting transient receptor potential channels for seizures and epilepsy: Emerging preclinical evidence of druggability.

Transient inhibition of microsomal prostaglandin E synthase-1 after status epilepticus blunts brain inflammation and is neuroprotective.

Ganaxolone for management of seizures associated with CDKL5 deficiency disorder.

Editorial: Neuroinflammation in acquired epilepsy

Collaborators (7)

Frank Park

Kelli Adeleye

Chao-Yie Yang

Najah Albadari

Yang Xie

Bernd Meibohm

Wei Li

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