Jin Wang

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Professor

Baylor College of Medicine

United States

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Recent Grants

Grant: Open

Development of First-in-Class RIPK1 Degraders to Improve Cancer Immunotherapies

Open Date: 2022-07-07

Close Date: 2027-06-30

Grant: Close

RIP PROTACs as a Novel Immunotherapy Sensitizer to Treat Colorectal Cancer

Open Date: 2022-02-16

Close Date:

Grant: Close

Developing Novel Soluble Epoxide Hydrolase Inhibitors for the Treatment of Alzheimer's Disease

Open Date: 2020-09-15

Close Date: 2025-05-31

Grant: Close

Reversible Covalent BTK Degraders as the Next Generation Targeted Therapy to Treat B-cell Malignancies

Open Date: 2020-07-01

Close Date: 2025-06-30

Grant: Close

Targeting a lipid-mediated pro-longevity pathway as Alzheimer's therapy

Open Date: 2018-09-15

Close Date: 2023-06-30

Articles (18)

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2024

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2022

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2022

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2022

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2022

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2022

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2021

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2021

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2021

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2021

Collaborators (6)

Dong Lu

Baylor College of Medicine

UNITED STATES

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Mingxing Teng

Assistant Professor

Baylor College of Medicine

UNITED STATES

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Austyn Colter

Indiana University School of Medicine

UNITED STATES

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Chi Zhang

Associate Professor

Indiana University School of Medicine

UNITED STATES

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B.V.Venkataram Prasad

Professor

Baylor College of Medicine

UNITED STATES

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SHA CAO

Assistant Professor

Indiana University School of Medicine

UNITED STATES

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Jin Wang

Research Interests

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Recent Grants

Articles (18)

CYP3A Mediates an Unusual C(sp2)−C(sp3) Bond Cleavage via Ipso‐Addition of Oxygen in Drug Metabolism

Development of Biochemical and Cellular Probes to Study RIPK1 Target Engagement

Lead Compound Development of SRC-3 Inhibitors with Improved Pharmacokinetic Properties and Anticancer Efficacy.

DAPK3 modulates migration and invasion of triple negative breast cancer cells

Evaluation of High-Affinity Monoclonal Antibodies and Antibody-Drug Conjugates by Homogenous Time-Resolved FRET

Lysineless HiBiT and NanoLuc Tagging Systems as Alternative Tools for Monitoring Targeted Protein Degradation

Glutathione dynamics in subcellular compartments and implications for drug development

Inhibition of SRC-3 as a potential therapeutic strategy for aggressive mantle cell lymphoma

Targeted Protein Degradation via Lysosomes

An active site loop toggles between conformations to control antibiotic hydrolysis and inhibition potency for CTX-M β-lactamase drug-resistance enzymes

Discovery of a potent BTK and IKZF1/3mg triple degrader through reversible covalent BTK PROTAC development

Lysosome lipid signalling from the periphery to neurons regulates longevity.

Fluorescent Probes and Mass Spectrometry-Based Methods to Quantify Thiols in Biological Systems

Applications of covalent chemistry in targeted protein degradation

MAL2 drives immune evasion in breast cancer by suppressing tumor antigen presentation.

Unique Diacidic Fragments Inhibit the OXA-48 Carbapenemase and Enhance the Killing of Escherichia coli Producing OXA-48

Expedient Total Syntheses of Pladienolide-Derived Spliceosome Modulators

An Arabidopsis Oxalyl-CoA Decarboxylase, AtOXC, Is Important for Oxalate Catabolism in Plants

Collaborators (6)

Dong Lu

Mingxing Teng

Austyn Colter

Chi Zhang

B.V.Venkataram Prasad

SHA CAO

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