Johann Matschke

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Germany

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Recent Grants

Grant: Close

GRK 2762: Heterogeneity, plasticity & dynamics in cancer cell, tumor and normal tissue responses to cancer radiotherapy

Open Date: 2022-01-01

Close Date:

Grant: Close

Verbundprojekt METABOLiST: Einfluss veränderter Stoffwechselwege auf die therapeutische Strahlenantwort von Tumoren, Teilprojekt B

Open Date: 2021-01-01

Close Date: 2023-12-31

Grant: Close

Metabolic induction of DNA repair defects for improving the outcome of radiotherapy.

Open Date: 2020-01-01

Close Date:

Articles (16)

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2025

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2021

Collaborators (11)

Thomas Helleday

Professor at Karolinska Institutet

Karolinska Institutet

SWEDEN

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Carsten Theiss

Ruhr-Universität Bochum

GERMANY

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Alexander Fabian

University Hospital Schleswig-Holstein

GERMANY

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Kathy Keyvani

Head/Professor

University of Duisburg-Essen Faculty of Medizin

GERMANY

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Verena Jendrossek

Head of Department

GERMANY

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Joachim Fandrey

Universitätsprofessor

Universität zu Köln Medizinische Fakultät

GERMANY

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Marc Spehr

Full Professor

RWTH Aachen University

GERMANY

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Matthias Vorgerd

GERMANY

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Björn Scheffler

University Hospital Essen

GERMANY

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Nicole Dünker

Prof.

Universität Duisburg-Essen

GERMANY

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Andreas Till

Lecturer & Group Leader

Rheinische Friedrich-Wilhelms-Universität Bonn

GERMANY

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Johann Matschke

Research Interests

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Recent Grants

Articles (16)

Balancing barriers: Family, career, and gender equality in radiation oncology and radiation research—An interdisciplinary prospective survey among the young workforce

Targeting hypoxia-inducible factor-1 in a hypoxidative stress model protects retinal pigment epithelium cells from cell death and metabolic dysregulation

Fructose induces metabolic reprogramming in liver cancer cells, promoting aggressiveness and chemotherapy resistance

Elevated NLRP3 Inflammasome Activation Is Associated with Motor Neuron Degeneration in ALS

α-Ketoglutarate supplementation and NAD+ modulation enhance metabolic rewiring and radiosensitization in SLC25A1 inhibited cancer cells

The second PI(3,5)P2 binding site in the S0 helix of KCNQ1 stabilizes PIP2-at the primary PI1 site with potential consequences on intermediate-to-open state transition

A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma

A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma

Cigarette smoke causes a bioenergetic crisis in RPE cells involving the downregulation of HIF-1α under normoxia

Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction

Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction

Accumulation of oncometabolite D-2-Hydroxyglutarate by SLC25A1 inhibition: A metabolic strategy for induction of HR-ness and radiosensitivity

Targeting AKT-Dependent Regulation of Antioxidant Defense Sensitizes AKT-E17K Expressing Cancer Cells to Ionizing Radiation

ROS scavengers decrease gamma H2ax spots in motor neuronal nuclei of ALS model mice in vitro

Metabolism of cancer cells commonly responds to irradiation by a transient early mitochondrial shutdown

Adaptation to Chronic-Cycling Hypoxia Renders Cancer Cells Resistant to MTH1-Inhibitor Treatment Which Can Be Counteracted by Glutathione Depletion

Collaborators (11)

Thomas Helleday

Carsten Theiss

Alexander Fabian

Kathy Keyvani

Verena Jendrossek

Joachim Fandrey

Marc Spehr

Matthias Vorgerd

Björn Scheffler

Nicole Dünker

Andreas Till

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