John Cooke

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Professor and Department Chair

Houston Methodist Research Institute

United States

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About

Professor John Cooke serves as the Department Chair at the Houston Methodist Research Institute in the United States. His research focuses on various areas including nucleic acid therapies, endothelial dysfunction, and the regeneration of cardiovascular tissues. Recent publications highlight his work on telomerase, mRNA therapy, and the cardiovascular implications of COVID-19. Professor Cooke's contributions bridge the disciplines of science, engineering, and medicine.

Recent Grants

Grant: Close

Telomerase therapy for progeria

Open Date: 2015-09-01

Close Date: 2016-08-01

Grant: Close

Cancer Prevention Institute of Texas RNA Core for Therapeutics and Research

Open Date: 2015-06-01

Close Date: 2020-05-01

Grant: Close

Telomere extension using nucleoside-modified mRNA and exosomes as a novel therapy of DMD

Open Date: 2012-09-01

Close Date: 2016-08-01

Grant: Close

Cell characterization and imaging for regenerative therapies in ischemic diseases

Open Date: 2012-04-01

Close Date: 2019-03-01

Grant: Close

Basic and translational research of iPSC-based hematologic and vascular therapies

Open Date: 2009-09-01

Close Date: 2016-04-01

Articles (15)

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2021

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UNITED STATES

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John Cooke

Research Interests

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About

Recent Grants

Articles (15)

Circular RNA Telomerase Reverses Endothelial Senescence in Progeria

Myocardial Recovery versus Myocardial Regeneration: Mechanisms and Therapeutic Modulation

Established and Emerging Nucleic Acid Therapies for Familial Hypercholesterolemia

β-catenin mRNA encapsulated in SM-102 lipid nanoparticles enhances bone formation in a murine tibia fracture repair model

Telomerase mRNA Enhances Human Skin Engraftment for Wound Healing

Is Cardiovascular Regeneration Possible?

Future Impact of mRNA Therapy on Cardiovascular Diseases

Vascular senescence in progeria: role of endothelial dysfunction

At the nexus of science, engineering, and medicine: Pasteur's quadrant reconsidered

New Directions in Therapeutic Angiogenesis and Arteriogenesis in Peripheral Arterial Disease

Acute and Chronic Cardiovascular Manifestations of COVID-19: Role for Endotheliopathy

Unsupervised Learning for Automated Detection of Coronary Artery Disease Subgroups

Fli1 + cells transcriptional analysis reveals an Lmo2–Prdm16 axis in angiogenesis

MACMIC Reveals A Dual Role of CTCF in Epigenetic Regulation of Cell Identity Genes

mRNA-Enhanced Cell Therapy and Cardiovascular Regeneration

Collaborators (8)

Abhishek Jain

Keith Youker

John H. Connor

Biana Godin

Li Lai

Brian Annex

Xueqin Gao

David F. Chang

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