John H. Adams

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Distinguished University Professor

University of South Florida

United States

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About

John H. Adams is a Distinguished University Professor at the University of South Florida, USA. His research primarily focuses on immunological responses to malaria, particularly involving Plasmodium vivax and Plasmodium falciparum. His recent articles cover topics such as memory B cell responses, genetic factors in gametocytogenesis, and the effects of co-infection with Epstein-Barr virus. Additionally, he investigates the potential of antimalarial targets and antibody responses in combating malaria.

Recent Grants

Grant: Close

Accelerating discovery of an efficacious Plasmodium vivax multivalent multi-stage vaccine

Open Date: 2020-12-01

Close Date: 2025-11-30

Grant: Close

Plasmodium ovale hypnozoite development and relapse: a coordinated in vivo in vitro study

Open Date: 2020-11-17

Close Date: 2022-10-31

Grant: Close

Antimalarial drug discovery targeting pre-erythrocytic stages of Plasmodium falciparum

Open Date: 2019-01-01

Close Date: 2021-08-01

Grant: Close

Discovering the essential genome of Plasmodium falciparum

Open Date: 2018-06-15

Close Date: 2022-05-31

Grant: Close

Structural vaccinology and design of novel immunogens for malaria vaccine development

Open Date: 2018-02-01

Close Date: 2023-01-01

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Collaborators (11)

Jeffrey Dvorin

Associate Professor

Harvard Medical School

UNITED STATES

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Olivier THOMAS

Established Professor in Marine Biodiscovery

University of Galway

IRELAND

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JI YOUN YOO

Assistant professor

University of Tennessee

UNITED STATES

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Maureen E. Groer

University of Tennessee

UNITED STATES

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Louise Allcock

Lecturer

National University of Ireland Galway

IRELAND

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David Serre

University of Maryland School of Medicine

UNITED STATES

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Xiaoming Liu

UNITED STATES

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Stije J. Leopold

Amsterdam University Medical Centers

NETHERLANDS

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Andreas Seyfang

Professor

University of South Florida

UNITED STATES

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Kimberly Fornace

University of Glasgow

UNITED KINGDOM

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Francis Ntumngia

Associate Professor

University of South Florida

UNITED STATES

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John H. Adams

Research Interests

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Recent Grants

Articles (26)

Correction: Cross-reactive inhibitory antibody and memory B cell responses to variant strains of Duffy binding protein II at post-Plasmodium vivax infection.

Supersaturation mutagenesis reveals adaptive rewiring of essential genes among malaria parasites.

Antibody response to Plasmodium vivax in the context of Epstein-Barr virus (EBV) co-infection: A 14-year follow-up study in the Amazon rainforest.

Atypical memory B cells from natural malaria infection produced broadly neutralizing antibodies against Plasmodium vivax variants.

Single-cell analyses of polyclonal Plasmodium vivax infections and their consequences on parasite transmission

Efficacy of ivermectin and its metabolites against Plasmodium falciparum liver stages in primary human hepatocytes

Oxidative stress changes the effectiveness of artemisinin in Plasmodium falciparum

Xeniaphyllane and Xeniolide Diterpenes from the Deep-Sea Soft Coral Paragorgia arborea

Genetic factors regulating Plasmodium falciparum gametocytogenesis identified by phenotypic screens.

The <i>Plasmodium falciparum</i> NCR1 transporter is an antimalarial target that exports cholesterol from the parasite's plasma membrane.

Polarization toward Tfh2 cell involved in development of MBC and antibody responses against Plasmodium vivax infection.

Multistage protective anti-CelTOS monoclonal antibodies with cross-species sterile protection against malaria.

Phenotypic Screens Identify Genetic Factors Associated with Gametocyte Development in the Human Malaria Parasite Plasmodium falciparum

A novel Modulator of Ring Stage Translation (MRST) gene alters artemisinin sensitivity in Plasmodium falciparum

Protein KIC5 is a novel regulator of artemisinin stress response in the malaria parasite Plasmodium falciparum.

Analytical approaches for antimalarial antibody responses to confirm historical and recent malaria transmission: an example from the Philippines

A pilot study: Validation of dried blood spots (DBS) to assess SARS-CoV2 IgG antibody immunoassays in underserved minority population

Characterization of Duffy Binding Protein II-specific CD4 <sup>+</sup>T cell responses in Plasmodium vivax patients

Chemogenomic Profiling of a Plasmodium falciparum Transposon Mutant Library Reveals Shared Effects of Dihydroartemisinin and Bortezomib on Lipid Metabolism and Exported Proteins

Genetic diversity and natural selection of Plasmodium vivax reticulocyte invasion genes in Ecuador

Heat-shock responses: systemic and essential ways of malaria parasite survival

Large DNA fragment knock-in and sequential gene editing in Plasmodium falciparum: a preliminary study using suicide-rescue-based CRISPR/Cas9 system

IgM antibody responses against Plasmodium antigens in neotropical primates in the Brazilian Atlantic Forest

Preliminary characterization of Plasmodium vivax sporozoite antigens as pre-erythrocytic vaccine candidates

MalariaSED: a deep learning framework to decipher the regulatory contributions of noncoding variants in malaria parasites

Intestinal injury and the gut microbiota in patients with Plasmodium falciparum malaria

Collaborators (11)

Jeffrey Dvorin

Olivier THOMAS

JI YOUN YOO

Maureen E. Groer

Louise Allcock

David Serre

Xiaoming Liu

Stije J. Leopold

Andreas Seyfang

Kimberly Fornace

Francis Ntumngia

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