John Hawdon

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Associate Professor

George Washington University

United States

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About

John Hawdon is an Associate Professor at George Washington University in the United States. His research focuses on the immunological aspects of hookworm infections, including host specificity and vaccine development. Recent publications include studies on the efficacy of Emodepside against drug-resistant hookworms and the immunological responses in various hookworm species.

Recent Grants

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Identification and validation of mutations causing naturally occurring multi-drug resistance in hookworm

Open Date: 2018-05-14

Close Date: 2020-04-30

Grant: Close

Determining the molecular mechanism of anthelmintic resistance in hookworms

Open Date: 2015-07-01

Close Date: 2017-06-30

Grant: Close

Developing genetic tools for a new model of infection and immunity

Open Date: 2014-05-16

Close Date: 2016-04-30

Grant: Close

Developing tools for genetic manipulation of hookworms

Open Date: 2013-04-15

Close Date: 2015-03-31

Grant: Close

Role of insulin-like signaling in the hookworm infective process

Open Date: 2007-09-01

Close Date: 2012-08-31

Articles (18)

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2020

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2020

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2020

Collaborators (6)

Sergej Djuranovic

Professor

Washington University School of Medicine

UNITED STATES

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Damien O'Halloran

George Washington University

UNITED STATES

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Alex Loukas

Distinguished Professor

James Cook University Cairns Campus

AUSTRALIA

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Maria Elena Bottazzi

Baylor College of Medicine

UNITED STATES

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Makedonka Mitreva

Professor

Washington University in Saint Louis School of Medicine

UNITED STATES

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Paul J. Brindley

Professor

George Washington University

UNITED STATES

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John Hawdon

Research Interests

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About

Recent Grants

Articles (18)

Manufacture of Necator americanus as an infectious challenge agent: Accelerating human hookworm vaccine development

Differential Emodepside Efficacy in Drug-Resistant and Drug-Susceptible Ancylostoma caninum Highlights Variability in Potassium Channel Activity

Sex-Specific Immune Responses Mediate Host Specificity in Hookworm Infections

Altered larval activation response associated with multidrug resistance in the canine hookworm Ancylostoma caninum

Immunity mediates host specificity in the human hookworm Ancylostoma ceylanicum

Excretory/Secretory Proteome of Females and Males of the Hookworm <i>Ancylostoma ceylanicum</i>

Excretory/Secretory Proteome of Females and Males of the Hookworm <i>Ancylostoma ceylanicum</i>

Comparative transcriptomics from intestinal cells of permissive and non-permissive hosts during <i>Ancylostoma ceylanicum</i> infection reveals unique signatures of protection and host specificity

Culturing and Genetically Manipulating Entomopathogenic Nematodes

MINI-BAERMANN FUNNEL, A SIMPLE DEVICE FOR CLEANING NEMATODE INFECTIVE LARVAE

Teaching Parasitology Lab Remotely Using Livestreaming

Chemogenomic approach to identifying nematode chemoreceptor drug targets in the entomopathogenic nematode Heterorhabditis bacteriophora

Secreted virulence factors from Heterorhabditis bacteriophora highlight its utility as a model parasite among Clade V nematodes.

A putative lysozyme and serine carboxypeptidase from Heterorhabditis bacteriophora show differential virulence capacities in Drosophila melanogaster

Chemogenomic approach to identifying nematode chemoreceptor drug targets in the entomopathogenic nematode Heterorhabditis bacteriophora

NemChR-DB: a database of parasitic nematode chemosensory G-protein coupled receptors.

A putative UDP-glycosyltransferase from Heterorhabditis bacteriophora suppresses antimicrobial peptide gene expression and factors related to ecdysone signaling.

Transcriptomic analysis of hookworm Ancylostoma ceylanicum life cycle stages reveals changes in G-protein coupled receptor diversity associated with the onset of parasitism.

Collaborators (6)

Sergej Djuranovic

Damien O'Halloran

Alex Loukas

Maria Elena Bottazzi

Makedonka Mitreva

Paul J. Brindley

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