John LaCava

Has grant

Principal Investigator, Associate Professor

University Medical Center Groningen

Netherlands

Research Interests

Explore related searches

Professors in Netherlands Professors in Immunology Immunology professors in Netherlands

Contact this professor

Get a free first email built on one of their papers, ready for you to edit and send yourself.

About

John LaCava is a Principal Investigator and Associate Professor at the University Medical Center Groningen, Netherlands. His research focuses on the roles of interferons, cytokines, and retrotransposon expression in autoimmune diseases and cancer immunogenicity. Recent publications include studies on the transcriptional activation of LINE-1 elements in myeloid cells and the interaction of various proteins in neuroinflammation and colitis.

Recent Grants

Grant: Close

Affinity capture / mass spectrometry screening combined with mass photometry to assess sample heterogeneity and predict macromolecular topologies

Open Date: 2020-01-01

Close Date: 2022-01-01

Grant: Close

Protein interactions mediate the contribution of LINE-1 retrotransposons to cancer development

Open Date: 2019-03-01

Close Date: 2021-02-28

Grant: Close

Diagnostic detection of L1 retrotransposons, a newly recognized hallmark of cancer

Open Date: 2019-02-01

Close Date: 2020-01-01

Grant: Close

An integrated pipeline for next-generation protein interactomics

Open Date: 2017-12-01

Close Date: 2021-11-30

Grant: Close

Monospecific monoclonal antibodies against human protein complexes on an interactome-wide scale.

Open Date: 2016-08-24

Close Date: 2017-07-31

Articles (17)

Year:

2025

Year:

2025

Year:

2024

Year:

2024

Year:

2024

Year:

2024

Year:

2024

Year:

2023

Year:

2023

Year:

2023

Year:

2023

Year:

2023

Year:

2023

Year:

2022

Year:

2022

Year:

CANADA

View details

Tomas Mustelin

Professor

University of Washington

UNITED STATES

View details

Weimin Zhang

Research Assistant Professor

New York University Grossman School of Medicine

UNITED STATES

View details

Jennifer Fairman

Associate Professor

Johns Hopkins University

UNITED STATES

View details

ApplyKite TwinLearns as you apply

Make your next move.

Prepare your application

Review drafts before you send them.

John LaCava

Research Interests

Explore related searches

Contact this professor

About

Recent Grants

Articles (17)

Interferons and Cytokines Induce Transcriptional Activation of the Long-Interspersed Element-1 in Myeloid Cells from Autoimmune Patients.

Targeted detection of endogenous LINE-1 proteins and ORF2p interactions.

CCDC88B interacts with RASAL3 and ARHGEF2 and regulates dendritic cell function in neuroinflammation and colitis

Multiparameter Screen Optimizes Immunoprecipitation

Cancer cells restrict immunogenicity of retrotransposon expression via distinct mechanisms.

Interrogating data-independent acquisition LC-MS/MS for affinity proteomics.

Subcellular location of L1 retrotransposon-encoded ORF1p, reverse transcription products, and DNA sensors in lupus granulocytes.

Expression of L1 retrotransposons in granulocytes from patients with active systemic lupus erythematosus.

Structures, functions, and adaptations of the human LINE-1 ORF2 protein.

Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker.

Consequences of a telomerase-related fitness defect and chromosome substitution technology in yeast <i>synIX</i> strains.

MsPHep: An online application for low molecular weight heparin rapid characterization based on liquid chromatography-tandem mass spectrometry.

Affinity-Based Interactome Analysis of Endogenous LINE-1 Macromolecules.

LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase checkpoint

Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome.

NCBP3 positively impacts mRNA biogenesis

High Prevalence and Disease Correlation of Autoantibodies Against p40 Encoded by Long Interspersed Nuclear Elements in Systemic Lupus Erythematosus

Collaborators (10)

Eddy Arnold

Martin Taylor

Kathleen Burns

Paolo Mita

Rayan Najjar

Jef Boeke

David Langlais

Tomas Mustelin

Weimin Zhang

Jennifer Fairman

Make your next move.