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John Melchior

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Biomedical Scientist

Pacific Northwest National Laboratory

United States

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Recent Grants

Grant: Open

The impact of brain lipoprotein structure and composition on amyloid beta metabolism and Alzheimer's disease

Open Date: 2024-07-15

Close Date: 2029-06-30

Grant: Close

Impact of apolipoprotein E isoforms on brain lipoproteins

Open Date: 2021-04-01

Close Date: 2023-03-31

Grant: Close

Apolipoprotein Structure in High Density Lipoprotein

Open Date: 2016-01-01

Close Date: 2017-12-31

Articles (19)

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Collaborators (18)

Song Feng

Assistant Professor

Baylor University

UNITED STATES

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David Pollock

Professor

University of Colorado Anschutz Medical Campus

UNITED STATES

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Matthew Monroe

Senior Research Scientist

Pacific Northwest National Laboratory

UNITED STATES

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Amy S. Shah

Division Director

Cincinnati Children's Hospital Medical Center

UNITED STATES

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Danielle Jensen

Professor

Gonzaga University

UNITED STATES

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Donna Wilcock

Professor

University of Kentucky

UNITED STATES

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Wei-Jun Qian

Staff Scientist

Pacific Northwest National Laboratory

UNITED STATES

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Pavlo Bohutskyi

Joint Faculty

Washington State University

UNITED STATES

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Snigdha Sarkar

Staff scientist

Fred Hutch Cancer Center

UNITED STATES

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Stephen G. Aller

Associate Professor

The University of Alabama

UNITED STATES

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Steven Wiley

Senior Scientist

Pacific Northwest National Laboratory

UNITED STATES

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Tao Liu

Sr. Staff Scientist

Pacific Northwest National Laboratory

UNITED STATES

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Anand Rohatgi

University of Texas Southwestern Medical Center

UNITED STATES

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Aaron Wright

James R. Schofield Endowed Chair in Biomedical Sciences

Baylor University

UNITED STATES

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Jason McDermott

Adjunct Assistant Professor

Oregon Health & Science University

UNITED STATES

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Kimberley Bruce

Associate Professor

University of Colorado Anschutz Medical Campus

UNITED STATES

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Pheruza Tarapore

Assistant Professor

University of Cincinnati Medical Center

UNITED STATES

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Linda Van Eldik

Director

University of Kentucky

UNITED STATES

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John Melchior

Research Interests

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Recent Grants

Articles (19)

Rapid Adaptation of Cyanobacteria to Environmental Perturbations Is Achieved Through Structural Remodeling of the Proteome

Aggregation Methods for Quantifying PTM and Structural Changes in Bottom-Up Proteomics

ProteoMeter: a pipeline for integrating multi-PTM and limited proteolysis data to reveal modification-structure coupling at the residue level

A model of human APOA2 on HDL

The Structural and Functional Journey of Apolipoprotein A-I Through the Human Body

Apolipoprotein A5 Reduces Clearance of Very Low-density Lipoprotein by Altering Apolipoprotein E Content

Human Coronavirus-229E Hijacks Key Host-Cell RNA-Processing Complexes for Replication

Lipid and lipoprotein metabolism in microglia: Alzheimer's disease mechanisms and interventions

An Integral Activity-Based Protein Profiling Method for Higher Throughput Determination of Protein Target Sensitivity to Small Molecules

The congenital APOA1 K107del mutation disrupts the lipid-free conformation of monomeric APOA1 and impairs oligomerization.

Harnessing Nanobodies for Precision Targeting of Proteoforms: Opportunities and Challenges in Therapeutics and Diagnostics.

A novel assay to measure low-density lipoproteins binding to proteoglycans.

APOA2 increases cholesterol efflux capacity to plasma HDL by displacing the C-terminus of resident APOA1

A fast and sensitive size‐exclusion chromatography method for plasma extracellular vesicle proteomic analysis

Lipoprotein Particles in Cerebrospinal Fluid

Human cerebrospinal fluid contains diverse lipoprotein subspecies enriched in proteins implicated in central nervous system health

Proteomic Determinants of Variation in Cholesterol Efflux: Observations from the Dallas Heart Study

Systematic review of type 1 diabetes biomarkers reveals regulation in circulating proteins related to complement, lipid metabolism, and immune response.

Lipoprotein subfraction patterns throughout gestation in The Gambia: changes in subfraction composition and their relationships with infant birth weights.

Collaborators (18)

Song Feng

David Pollock

Matthew Monroe

Amy S. Shah

Danielle Jensen

Donna Wilcock

Wei-Jun Qian

Pavlo Bohutskyi

Snigdha Sarkar

Stephen G. Aller

Steven Wiley

Tao Liu

Anand Rohatgi

Aaron Wright

Jason McDermott

Kimberley Bruce

Pheruza Tarapore

Linda Van Eldik

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