João Peça

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Assistant Professor

University of Coimbra

Portugal

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About

João Peça is an Assistant Professor at the University of Coimbra, Portugal. His research focuses on neurodevelopment and brain editing techniques, with recent publications exploring topics such as microglial changes due to early-life interventions, genetic variants associated with severe epilepsy, and innovative applications of CRISPR-Cas9 for brain gene editing. He also investigates maternal behaviors impacting neurodevelopmental trajectories and the engineering of tools for brain stimulation and regeneration.

Recent Grants

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Th2brain: Effects of Th2-related immunity in the postnatal maturation of brain circuits

Open Date: 2023-01-01

Close Date:

Grant: Close

SHANKAstro: Astrocytes dysfunctions in Phelan-McDermid syndrome: from mechanisms towards new therapeutic strategies

Open Date: 2022-05-01

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BrainCils: Neuronal primary cilia and chromatin dysregulation - Exploring the missing link in neurodevelopmental disorders using brain organoids

Open Date: 2022-01-01

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Postnatal Reorganization of the cerebellum via Neuron-microglia interaction: IL-4 as a mediator between ADHD and allergies

Open Date: 2021-02-01

Close Date:

Grant: Close

The social code in cingulate-hippocampal circuits

Open Date: 2021-02-01

Close Date:

João Peça

Research Interests

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About

Recent Grants

Articles (17)

Early‐life IL‐4 administration induces long‐term changes in microglia in the cerebellum and prefrontal cortex

Maternal behaviours disrupted by Gprasp2 deletion modulate neurodevelopmental trajectory in progeny

Near-Infrared Light Activated Formulation for the Spatially Controlled Release of CRISPR-Cas9 Ribonucleoprotein for Brain Gene Editing

A Novel Genetic Variant in MBD5 Associated with Severe Epilepsy and Intellectual Disability: Potential Implications on Neural Primary Cilia

Engineering optical tools for remotely controlled brain stimulation and regeneration

In vivo recordings in freely behaving mice using independent silicon probes targeting multiple brain regions

IL-4 shapes microglia-dependent pruning of the cerebellum during postnatal development

Brain Gain – Discovering Neurosciences: A digital education outreach project for higher education students

Scaffolds for Dentin–Pulp Complex Regeneration

Attenuation of Autism-like Behaviors by an Anthocyanin-Rich Extract from Portuguese Blueberries via Microbiota–Gut–Brain Axis Modulation in a Valproic Acid Mouse Model

Efficient spatially targeted gene editing using a near-infrared activatable protein-conjugated nanoparticle for brain applications

Microglia‐dependent remodeling of neuronal circuits

Generation and Characterization of Novel iPSC Lines from a Portuguese Family Bearing Heterozygous and Homozygous GRN Mutations

Ligand-independent activity of the ghrelin receptor modulates AMPA receptor trafficking and supports memory formation.

The old guard: Age-related changes in microglia and their consequences

Regeneration of pulp-dentin complex using human stem cells of the apical papilla: in vivo interaction with two bioactive materials

Distinct subnetworks of the thalamic reticular nucleus

Collaborators (19)

Stefan Stricker

lino ferreira

Daniel Choquet

Pedro Martins Carvalho

Diana Serra

Sara Varela Amaral

Mário Carvalho

Diana B. Sequeira

Victor Freitas

João Miguel Marques dos Santos

Michael Halassa

Patricio Opazo

Paulo J. Palma

Catarina Morais Seabra

Ana Carolina Bione Kunicki Peres

Sonia Pinho

Gabriela Jorge Da Silva

Guiomar Oliveira

Ana Luisa Carvalho

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