Jorge Ruas at Karolinska Institutet - Research Interests, Publications & Academic Profile

Jorge Ruas

Professor of Molecular Physiology

Karolinska Institutet

Sweden

Has grant

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Research Interests

Cell Biology

70%

Biochemistry

70%

Metabolic Biology

60%

Beta Cell

40%

Cardiovascular Biology

30%

Ischemic Physiology

20%

Actin

20%

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Recent Grants

Grant: Open

NEW MOLECULAR TARGETS AND BIOMARKERS FOR NON-ALCOHOLIC FATTY LIVER DISEASE AND STEATOHEPATITIS (NAFLD/NASH)

Open Date: 2023-01-01

Close Date: 2026-12-01

Grant: Close

Regulation of Peripheral Insulin Sensitivity by Neuroendocrine Communication and Kynurenine Metabolites

Open Date: 2023-01-01

Close Date: 2025-12-01

Grant: Close

TRAIN and NAFLD

Open Date: 2019-01-01

Close Date: 2024-01-01

Grant: Close

NNF Research Grant

Open Date: 2017-07-01

Close Date: 2020-06-01

Grant: Close

VR Consolidator Grant

Open Date: 2017-01-01

Close Date: 2022-12-01

Articles14

Multivalent insulin receptor activation using insulin–DNA origami nanostructures

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Year:

2024

Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition.

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2024

Improving human mesenchymal stem cell-derived hepatic cell energy metabolism by manipulating glucose homeostasis and glucocorticoid signaling

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Year:

2023

Epiblast-like stem cells established by Wnt/β-catenin signaling manifest distinct features of formative pluripotency and germline competence

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Year:

2023

Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and regeneration

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Year:

2023

NPC1-like phenotype, with intracellular cholesterol accumulation and altered mTORC1 signaling in models of Parkinson's disease.

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Year:

2023

Sustained PGC-1α2 or PGC-1α3 expression induces astrocyte dysfunction and degeneration.

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Year:

2023

PGC-1α4 Interacts with REST to Upregulate Neuronal Genes and Augment Energy Consumption in Developing Cardiomyocytes

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Year:

2022

Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome.

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Year:

2022

Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify receptor-transducer coupling and mediate intracellular pathway bias.

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Year:

2022

HIF-1α inhibitor PX-478 preserves pancreatic β cell function in diabetes

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Year:

2022

PGC-1α deficiency reveals sex-specific links between cardiac energy metabolism and EC-coupling during development of heart failure in mice

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Year:

2022

SnapShot: Regulation and biology of PGC-1α.

Article Link

Year:

2022

Full-length transcriptomic analysis in murine and human heart reveals diversity of PGC-1α promoters and isoforms regulated distinctly in myocardial ischemia and obesity

Article Link

Year:

2022

Collaborators14

Susanne Schlisio

Associate Professor

Karolinska Institutet

SWEDEN

Per-Olof Berggren

Professor

Karolinska Institutet

SWEDEN

Anna Smed Sörensen

Karolinska Institutet

SWEDEN

Georges Kiriako

Karolinska Institutet

SWEDEN

Petra Bullova

Karolinska Institutet

SWEDEN

Vanessa A Morais

Universidade de Aveiro

PORTUGAL

xingqi chen

Associate professor of molecular medicine, group leader

Uppsala University

SWEDEN

Erwin Ilegems

Karolinska Institutet

SWEDEN

Antonio Lentini

Karolinska Institutet

SWEDEN

Gunnar Schulte

Professor

Karolinska Institutet

SWEDEN

Qiaolin Deng

Karolinska Institutet

SWEDEN

Marie Arsenian Henriksson

Karolinska Institutet

SWEDEN

Sophie Petropoulos

Karolinska Institutet

SWEDEN

Jennifer Estall

Associate Research Professor

Institut de recherches cliniques de Montréal

CANADA

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