Gunnar Schulte

Karolinska Institutet is offering a fully funded PhD position in the Molecular Pharmacology of GPCRs team, led by Assistant Professor Paweł Kozielewicz, focusing on the mechanisms of activation and signaling of orphan G protein-coupled receptors (GPCRs) in cancer cells. The research aims to uncover novel interactions and signaling pathways of orphan GPCRs, with the goal of developing new therapeutic strategies for cancer. The project utilizes advanced techniques such as proximity labeling, CRISPR-Cas9 genome engineering, proteomics, and BRET-based biosensors, and involves both experimental and in silico approaches to ligand discovery. The doctoral student will plan and perform laboratory experiments, generate and validate engineered cell lines and biosensors, analyze proteomics and BRET datasets, and contribute to ligand identification. The project is highly collaborative, including work with Prof. Gunnar Schulte (Karolinska Institutet) and Prof. Sandro Cosconati (University of Campania Luigi Vanvitelli, Italy) for computational ligand screening and molecular modeling. The student will participate in internal and external meetings, doctoral courses, and teaching activities, with strong support for producing high-quality, publishable research. Applicants must have a master's degree or equivalent in a relevant field, or have completed at least 240 credits with at least 60 at the master's level. Proficiency in English (equivalent to Swedish upper secondary school English B/6) is required. Substantial, documented experience in receptor pharmacology, molecular biology, cell biology, and data analysis is necessary. Prior experience in GPCR pharmacology is a strong merit, and skills in bioinformatics are valuable. Candidates should demonstrate strong organizational and communication skills, a proactive attitude, and the ability to work both independently and collaboratively. The position is a full-time doctoral studentship for up to 4 years, with a contractual monthly salary. Employees have access to a modern gym for free and receive reimbursements for medical care. Karolinska Institutet is one of the world's leading medical universities, offering a creative and inspiring environment with opportunities for international exchanges. The application deadline is December 24, 2025. Applications should be submitted through the Varbi recruitment system, including a personal letter, CV, degree projects, publications, and documents certifying eligibility. For more information, contact Assistant Professor Paweł Kozielewicz at [email protected].

Karolinska Institutet is recruiting a Postdoctoral Fellow in Environmental Physiology within the Division of Environmental Physiology at the Department of Physiology and Pharmacology in Stockholm, Sweden. The project focuses on experimental human studies examining physiological responses to environmental and operational stressors, including altered ambient pressure, acceleration, temperature variation, sleep deprivation, fatigue, hypobaric and hyperbaric exposures, and decompression strain. The research sits at the intersection of human performance, aviation physiology, diving medicine, cardiovascular physiology, and autonomic regulation . The successful candidate will work primarily at the Campus Solna laboratories and may also participate in field-based experimental studies. Responsibilities include experimental planning and execution, data collection and analysis, interpretation of results, manuscript preparation, lab management, undergraduate teaching, and supervision of master’s and doctoral students. Eligibility highlights: a PhD in environmental physiology or a closely related field, or equivalent scientific competence by the end of the application period; documented experience with human physiological experiments; continuous cardiovascular monitoring; HRV and baroreflex analysis; echocardiography and vascular ultrasound; and exercise physiology methods such as maximal oxygen uptake testing. English fluency is required, while Swedish is advantageous. Experience in aviation/decompression physiology, cardiac imaging, venous gas emboli detection, sleep deprivation/fatigue physiology, and human biological sample handling is considered beneficial. Funding and appointment: this is a full-time temporary postdoctoral position for 1 year with potential prolongation. Karolinska Institutet notes standard employee benefits, including holiday, occupational pension, gym access, and medical care reimbursements. No stipend amount is stated. Application window: applications are due by 20 August 2026 and must be submitted through the Varbi recruitment system. Required documents include a CV, publication list, one-page research summary, motivation letter, and contact information for at least two academic references. Contacts: Antonis Elia (Assistant Professor) and Gunnar Schulte (Professor) are listed as contacts for the position.