Joris Deelen

Associate professor

Leiden University Medical Center

Netherlands

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About

Joris Deelen is an Associate Professor at Leiden University Medical Center in the Netherlands. His research focuses on the genetics of human longevity, including the exploration of rare genetic variants and metabolic biomarkers associated with age-related diseases. Recent articles highlight his work on the MAPK/ERK signaling pathway, geroprotective agents, and the molecular functions of genetic variants linked to human aging.

Articles (10)

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2025

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2025

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2024

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2024

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2024

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2023

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2022

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2021

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2020

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2020

Collaborators (8)

Linda Partridge

Max Planck Institute for Biology of Ageing

GERMANY

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Erik van den Akker

Delft University of Technology

NETHERLANDS

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René Pool

University of Amsterdam

NETHERLANDS

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Marcel Reinders

Delft University of Technology

NETHERLANDS

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Gonneke Willemsen

University of Amsterdam

NETHERLANDS

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Sebastian Grönke

Max Planck Institute for Biology of Ageing

GERMANY

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Jacob Daane

Assistant Professor

University of Houston

UNITED STATES

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Peter Joshi

University of Edinburgh

UNITED KINGDOM

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Joris Deelen

Research Interests

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Articles (10)

Functional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants

The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan

Intermittent rapamycin feeding recapitulates some effects of continuous treatment while maintaining lifespan extension

NMR metabolomics-guided DNA methylation mortality predictors

Genetics of human longevity: From variants to genes to pathways

Convergent genomics of longevity in rockfishes highlights the genetics of human life span variation

From mutation to mechanism: deciphering the molecular function of genetic variants linked to human ageing

Publisher Correction: A meta-analysis of genome-wide association studies identifies multiple longevity genes

Multivariate genomic scan implicates novel loci and haem metabolism in human ageing

Metabolic Age Based on the BBMRI-NL 1 H-NMR Metabolomics Repository as Biomarker of Age-related Disease

Collaborators (8)

Linda Partridge

Erik van den Akker

René Pool

Marcel Reinders

Gonneke Willemsen

Sebastian Grönke

Jacob Daane

Peter Joshi

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