Joseph Lachance

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Associate Professor

Georgia Institute of Technology

United States

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About

Joseph Lachance is an Associate Professor at the Georgia Institute of Technology in the United States. His research focuses on the genetic architecture and evolutionary dynamics of prostate cancer and androgenetic alopecia, with a particular emphasis on ancestral diversity and population genetics in African men. His recent publications highlight the identification of novel susceptibility variants and the complexities of genetic admixture in diverse populations.

Recent Grants

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Evolution of genetic disease risks over time and space

Open Date: 2019-09-05

Close Date: 2024-07-31

Articles (15)

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Collaborators (16)

Robert Klein

Associate Professor

Icahn School of Medicine at Mount Sinai

UNITED STATES

Joseph Lachance

Research Interests

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About

Recent Grants

Articles (15)

Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups

Uncovering the genetic architecture and evolutionary roots of androgenetic alopecia in African men

Heterogeneous genetic architectures of prostate cancer susceptibility in sub-Saharan Africa

Pan-African analysis identifies genetic differences in prostate cancer risk

Does Effective Population Size Govern Evolutionary Differences in Telomere Length?

Evidence of Novel Susceptibility Variants for Prostate Cancer and a Multiancestry Polygenic Risk Score Associated with Aggressive Disease in Men of African Ancestry.

Evolutionary Genetics and Admixture in African Populations

Challenges of accurately estimating sex-biased admixture from X chromosomal and autosomal ancestry proportions

Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

Genome of the endangered Guatemalan Beaded Lizard, Heloderma charlesbogerti, reveals evolutionary relationships of squamates and declines in effective population sizes

Hybrid fitness effects modify fixation probabilities of introgressed alleles

Adaptive eQTLs reveal the evolutionary impacts of pleiotropy and tissue-specificity while contributing to health and disease

Beyond Stamp Collecting: Evolutionary and Functional Genomics Advance Our Understanding of Cancer Biology

Large sample spaces do not imply biological systems are ‘fine-tuned’

A custom genotyping array reveals population-level heterogeneity for the genetic risks of prostate cancer and other cancers in Africa

Collaborators (16)

Robert Klein

Ian M. Thompson

FEI CHEN

Rebecca Graff

Paul Townsend

Michael Goodisman

Aswin George Abraham

Yong-Jie Lu

Yili Xu

Manuel António Rodrigues Teixeira

Rosalind Eeles

Burcu F Darst

Ilir Agalliu

Elaine Ostrander

Luc Multigner

Catharine West

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