Ju-hyun Lee

Assistnat Professor

NYU Langone Medical Center

United States

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Articles (7)

Year:

2023

Year:

2023

Year:

2022

Year:

2022

Year:

2022

Year:

2020

Year:

2020

Collaborators (3)

Eunju Im

Nathan Kline Institute for Psychiatric Research

UNITED STATES

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Thomas neubert

Professor

NYU School of Medicine

UNITED STATES

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Ralph A Nixon

Professor

New York University

UNITED STATES

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Ju-hyun Lee

Research Interests

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Articles (7)

Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr 682 -phosphorylated APP βCTF

Autophagy is a novel pathway for neurofilament protein degradation <i>in vivo</i>

Autolysosomal acidification failure as a primary driver of Alzheimer disease pathogenesis

Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques

Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca 2+ efflux and disrupted by PSEN1 loss of function

Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease

β2-adrenergic Agonists Rescue Lysosome Acidification and Function in PSEN1 Deficiency by Reversing Defective ER-to-lysosome Delivery of ClC-7

Collaborators (3)

Eunju Im

Thomas neubert

Ralph A Nixon

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