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Ju-hyun Lee

Assistnat Professor

NYU Langone Medical Center

United States

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Research Interests

Cell Biology

60%

Biochemistry

50%

Autophagy

40%

Proteostasis

40%

Membrane Trafficking

30%

Lysosome

30%

Neurodegenerative Disease

20%

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Articles7

Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr 682 -phosphorylated APP βCTF

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Year:

2023

Autophagy is a novel pathway for neurofilament protein degradation <i>in vivo</i>

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Year:

2023

Autolysosomal acidification failure as a primary driver of Alzheimer disease pathogenesis

Article Link

Year:

2022

Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques

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Year:

2022

Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca 2+ efflux and disrupted by PSEN1 loss of function

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Year:

2022

Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease

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Year:

2020

β2-adrenergic Agonists Rescue Lysosome Acidification and Function in PSEN1 Deficiency by Reversing Defective ER-to-lysosome Delivery of ClC-7

Article Link

Year:

2020

Collaborators3

Eunju Im

Nathan Kline Institute for Psychiatric Research

UNITED STATES

Thomas neubert

Professor

NYU School of Medicine

UNITED STATES

Ralph A Nixon

Professor

New York University

UNITED STATES

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