Juha Savinainen

University Lecturer

University of Eastern Finland

Finland

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About

Juha Savinainen is a University Lecturer at the University of Eastern Finland. His research focuses on endocannabinoid metabolism, prolyl oligopeptidase functions, and their implications in neurological and pain disorders. Recent articles include studies on the modulation of tau pathology and the pharmacological evaluation of FASN inhibitors, contributing significantly to our understanding of pain mechanisms and potential therapeutic strategies. He is based in Finland.

Articles (9)

Year:

2024

Year:

2023

Year:

2023

Year:

2023

Year:

2022

Year:

2022

Year:

2021

Year:

2020

Professor of Cell Biology

FINLAND

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Reinis Svarcbahs

University of Helsinki

FINLAND

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Juha Savinainen

Research Interests

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About

Articles (9)

5-Aminothiazoles Reveal a New Ligand-Binding Site on Prolyl Oligopeptidase Which is Important for Modulation of Its Protein–Protein Interaction-Derived Functions

A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy

Utilizing PET and MALDI Imaging for Discovery of a Targeted Probe for Brain Endocannabinoid α/β-Hydrolase Domain 6 (ABHD6)

Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain

Metabolomics of Synovial Fluid and Infrapatellar Fat Pad in Patients with Osteoarthritis or Rheumatoid Arthritis

Inhibiting Endocannabinoid Hydrolysis as Emerging Analgesic Strategy Targeting a Spectrum of Ion Channels Implicated in Migraine Pain

Distinct Activity of Endocannabinoid-Hydrolyzing Enzymes MAGL and FAAH in Key Regions of Peripheral and Central Nervous System Implicated in Migraine

High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections – Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils

Evaluation of FASN inhibitors by a versatile toolkit reveals differences in pharmacology between human and rodent FASN preparations and in antiproliferative efficacy in vitro vs. in situ in human cancer cells.

Collaborators (13)

Jari Yli-Kauhaluoma

Jayendra Z. Patel

Maria Jäntti

Hermina Jakupović

Muneer Ahamed

Henri Huttunen

Natasha Grimsey

Erik A. A. Wallén

Timo Myöhänen

Henri Pätsi

Pieter Van Wielendaele

Rashid Giniatullin

Reinis Svarcbahs

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