Timo Myöhänen

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University of Helsinki

Finland

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Recent Grants

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Novel PREP ligands to combat neurodegenerative diseases

Open Date: 2019-01-01

Close Date: 2020-12-01

Grant: Close

PREP as a common target for neurodegenerative disorders

Open Date: 2018-09-01

Close Date: 2022-08-01

Grant: Close

Prolyl oligopeptidase in neurodegeneration

Open Date: 2016-12-01

Close Date: 2018-12-01

Grant: Close

Prolyl oligopeptidase ligands, a common therapy for neurodegenerative diseases

Open Date: 2016-10-01

Close Date: 2018-09-01

Grant: Close

Prolyl oligopeptidase in neurodegeneration

Open Date: 2016-05-01

Close Date: 2018-05-01

Articles (14)

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2025

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2021

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2021

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2021

Collaborators (9)

Teppo Leino

University of Helsinki

FINLAND

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Maria Jäntti

University of Helsinki

FINLAND

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Henri Huttunen

University of Helsinki

FINLAND

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Erik A. A. Wallén

University of Helsinki

FINLAND

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Henri Pätsi

University of Helsinki

FINLAND

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Pieter Van Wielendaele

University of Antwerp

BELGIUM

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Juha Savinainen

University Lecturer

University of Eastern Finland

FINLAND

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Risto Kostiainen

University of Helsinki

FINLAND

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Reinis Svarcbahs

University of Helsinki

FINLAND

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Timo Myöhänen

Research Interests

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Contact this professor

Recent Grants

Articles (14)

A prolyl oligopeptidase ligand blocks memory deficit in a repeated mild traumatic brain injury model

5-Aminothiazoles Reveal a New Ligand-Binding Site on Prolyl Oligopeptidase Which is Important for Modulation of Its Protein–Protein Interaction-Derived Functions

A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy

Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on alpha-Synuclein Mouse Models of Parkinson's Disease

Nigrostriatal 6-hydroxydopamine lesions increase alpha-synuclein levels and permeability in rat colon

Removal of proteinase K resistant alpha Syn species does not correlate with cell survival in a virus vector-based Parkinson's disease mouse model

Prolyl oligopeptidase acts as a link between chaperone-mediated autophagy and macroautophagy

Inhibition of prolyl oligopeptidase

Prolyl oligopeptidase inhibition reduces oxidative stress via reducing NADPH oxidase activity by activating protein phosphatase 2A.

Prolyl Oligopeptidase Regulates Dopamine Transporter Oligomerization and Phosphorylation in a PKC- and ERK-Independent Manner.

Multiplexed analysis of amino acids in mice brain microdialysis samples using isobaric labeling and liquid chromatography-high resolution tandem mass spectrometry

2-Imidazole as a Substitute for the Electrophilic Group Gives Highly Potent Prolyl Oligopeptidase Inhibitors

Prolyl oligopeptidase inhibition reduces alpha-synuclein aggregation in a cellular model of multiple system atrophy

Deletion or inhibition of prolyl oligopeptidase blocks lithium-induced phosphorylation of GSK3b and Akt by activation of protein phosphatase 2A

Collaborators (9)

Teppo Leino

Maria Jäntti

Henri Huttunen

Erik A. A. Wallén

Henri Pätsi

Pieter Van Wielendaele

Juha Savinainen

Risto Kostiainen

Reinis Svarcbahs

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