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Julia Schulze-Hentrich

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University professor

Saarland University

Germany

Research Interests

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About

Julia Schulze-Hentrich is a University Professor at Saarland University in Germany. Her research primarily focuses on the molecular mechanisms of leukemia and neurodegenerative diseases, with recent articles exploring topics such as the role of Polo-like Kinase 1 in leukemia therapy and the association of cytochrome P450 SNPs with Parkinson's disease. Additionally, she has contributed to the development of data infrastructures for rare disease research and investigated the impact of early life adversities on adult mental health through blood transcriptome analyses.

Recent Grants

Grant: Close

Design and use of EpiEditors to mitigate alpha-synuclein overload in Parkinson’s disease and related synucleinopathies

Open Date: 2021-01-01

Close Date:

Grant: Close

EpiProspects: Evaluating prospects of epigenome profiling in unsolved syndromal cases

Open Date: 2021-01-01

Close Date:

Grant: Close

warp’d: Integrating transcriptome and DNA methylome data to discern accelerated from delayed adaptations in the unfolding of Parkinson’s disease

Open Date: 2021-01-01

Close Date:

Grant: Close

DEcipher the ComplexIty and Plasticity of epigenomic cHaracteristics under influence of Environmental factors in the pathomechanistic Regulation of PD – decipherPD

Open Date: 2016-03-20

Close Date: 2018-03-19

Grant: Close

Genom-weite Analyse epigenetischer DNA- und Chromatin-Modifikationen des Morbus Parkinson

Open Date: 2012-01-01

Close Date: 2014-12-31

Articles (15)

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2024

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2024

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2024

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2024

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2023

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2023

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2023

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2022

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2022

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2022

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2022

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2022

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2021

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2021

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2021

Collaborators (12)

Claire-Sophie Davoine

Institut du Cerveau et de la Moelle Épinière

FRANCE

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André Koch

University of Tübingen

GERMANY

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Oliver Kohlbacher

University of Tübingen

GERMANY

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Richarda M de Voer

Assistant professor

Radboudumc

NETHERLANDS

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Claudia Lengerke

Vice Dean

University Hospital Tübingen

GERMANY

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Birte Zurek, PhD

University Hospital Tübingen

GERMANY

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Michael Kobor

Professor and Canada Research Chair

University of British Columbia Faculty of Medicine

CANADA

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Mallory Freeberg

Human Genomics Team lead

European Bioinformatics Institute

UNITED KINGDOM

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Marek Turnovec

University Hospital in Motol

CZECH REPUBLIC

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Davide Mei

Dirigente Professioni Sanitarie Tecnico Diagnostiche

ITALY

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Thomas Hentrich

Saarland University

GERMANY

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Katharina Rall

University of Tübingen

GERMANY

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Julia Schulze-Hentrich

Research Interests

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About

Recent Grants

Articles (15)

The RORɣ/SREBP2 pathway is a master regulator of cholesterol metabolism and serves as potential therapeutic target in t(4;11) leukemia

Only Infant <i>MLL</i>-Rearranged Leukemia Is Susceptible to an Inhibition of Polo-like Kinase 1 (PLK-1) by Volasertib

SNPs in cytochromes P450 catalyzing cholesterol degradation in brain are associated with Parkinson's disease.

An interconnected data infrastructure to support large-scale rare disease research.

Blood transcriptome analysis suggests an indirect molecular association of early life adversities and adult social anxiety disorder by immune-related signal transduction.

miR-101a-3p Impairs Synaptic Plasticity and Contributes to Synucleinopathy.

Targeting MYC in combination with epigenetic regulators induces synergistic anti-leukemic effects in MLLr leukemia and simultaneously improves immunity

Alpha-synuclein overexpression induces epigenomic dysregulation of glutamate signaling and locomotor pathways.

Genome Sequencing and Transcriptome Profiling in Twins Discordant for Mayer-Rokitansky-Küster-Hauser Syndrome.

Failure of diet-induced transcriptional adaptations in alpha-synuclein transgenic mice.

Endometrial organoids derived from Mayer–Rokitansky–Küster–Hauser syndrome patients provide insights into disease-causing pathways

Editorial: Neuroepigenetics of Neuropsychiatric Disease—Hope, Success and Obstacles for Translational Findings and Applications

Solve-RD: systematic pan-European data sharing and collaborative analysis to solve rare diseases

Solving patients with rare diseases through programmatic reanalysis of genome-phenome data.

A Novel SCA3 Knock-in Mouse Model Mimics the Human SCA3 Disease Phenotype Including Neuropathological, Behavioral, and Transcriptional Abnormalities Especially in Oligodendrocytes

Collaborators (12)

Claire-Sophie Davoine

André Koch

Oliver Kohlbacher

Richarda M de Voer

Claudia Lengerke

Birte Zurek, PhD

Michael Kobor

Mallory Freeberg

Marek Turnovec

Davide Mei

Thomas Hentrich

Katharina Rall

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