Julien Muffat

Assistant Professor

University of Toronto Faculty of Medicine

Canada

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About

Dr. Julien Muffat is an Assistant Professor at the University of Toronto Faculty of Medicine in Canada. His research focuses on neuroimmune interactions, neural development, and the application of advanced technologies, such as in vivo brain organoids and CRISPR screens, to study neurodevelopmental disorders and neurodegenerative diseases. His recent publications explore the roles of mTOR pathways, genetic modulation in cancer-associated fibroblasts, and the use of human pluripotent stem cells to model brain diseases.

Articles (11)

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2025

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2025

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2024

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2024

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2023

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2023

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2021

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2021

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2021

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2020

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2020

Collaborators (4)

Helene Hirbec

University of Montpellier

FRANCE

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Martin Trapecar

Assistant Professor

Johns Hopkins University School of Medicine

UNITED STATES

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Wendy Wang

Broad Institute

UNITED STATES

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Yun Li

Assistant Professor

University of Toronto

CANADA

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Julien Muffat

Research Interests

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About

Articles (11)

Expanding the neuroimmune research toolkit with in vivo brain organoid technologies.

mTORC1 and mTORC2 synergy in human neural development, disease, and regeneration.

The use of a multi-metric readout screen to identify EHMT2/G9a-inhibition as a modulator of cancer-associated fibroblast activation state.

Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids.

Universal, label-free, single-molecule visualization of DNA origami nanodevices across biological samples using origamiFISH

Understanding neural development and diseases using CRISPR screens in human pluripotent stem cell-derived cultures

Modeling Developmental Brain Diseases Using Human Pluripotent Stem Cells-Derived Brain Organoids - Progress and Perspective.

Modeling PTEN overexpression-induced microcephaly in human brain organoids.

Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases.

Studying Human Neurodevelopment and Diseases Using 3D Brain Organoids.

Emerging technologies to study glial cells.

Collaborators (4)

Helene Hirbec

Martin Trapecar

Wendy Wang

Yun Li

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