Yun Li

Assistant Professor

University of Toronto

Canada

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About

Dr. Yun Li is an Assistant Professor at the University of Toronto, Canada. Her research focuses on neural development and disease, utilizing advanced techniques such as in vivo brain organoid technologies and CRISPR-Cas9 gene editing. Recent publications include investigations into mTORC1 and mTORC2 pathways in human neurons, as well as modeling epilepsy and developmental brain diseases using human pluripotent stem cell-derived cultures.

Articles (12)

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2026

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2025

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2024

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2024

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2024

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2023

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2023

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2022

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2021

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2021

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2021

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2020

Collaborators (3)

Wendy Wang

Broad Institute

UNITED STATES

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Julien Muffat

Assistant Professor

University of Toronto Faculty of Medicine

CANADA

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Lu-Yang Wang

Assistant, Associate & Full Professor

University of Toronto

CANADA

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Yun Li

Research Interests

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About

Articles (12)

mTORC1 and mTORC2 synergy in human neural development, disease, and regeneration

Expanding the neuroimmune research toolkit with in vivo brain organoid technologies.

Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids.

Human pluripotent stem cell-derived models of the hippocampus

Protocol for the efficient and inducible generation of CRISPR-Cas9-edited human cortical neurons from the iCas9-iNgn2 hPSCs

Universal, label-free, single-molecule visualization of DNA origami nanodevices across biological samples using origamiFISH

Understanding neural development and diseases using CRISPR screens in human pluripotent stem cell-derived cultures

Modeling Epilepsy Using Human Induced Pluripotent Stem Cells-Derived Neuronal Cultures Carrying Mutations in Ion Channels and the Mechanistic Target of Rapamycin Pathway.

Modeling Developmental Brain Diseases Using Human Pluripotent Stem Cells-Derived Brain Organoids - Progress and Perspective.

Modeling PTEN overexpression-induced microcephaly in human brain organoids.

Introductions to the Community: Early-Career Researchers in the Time of COVID-19.

Studying Human Neurodevelopment and Diseases Using 3D Brain Organoids

Collaborators (3)

Wendy Wang

Julien Muffat

Lu-Yang Wang

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