Kaiwen W Chen

Assistant Professor

National University of Singapore (NUS)

Singapore

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About

Dr. Kaiwen W Chen is an Assistant Professor at the National University of Singapore. His research focuses on cell death pathways, inflammasome signaling, and the role of gasdermins in inflammation and infection. Recent publications highlight the interplay between T3SS effectors and host responses, as well as the differentiated signaling mechanisms in immune cells during various pathogenic challenges.

Articles (16)

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2025

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2025

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2024

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2024

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2022

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2022

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2022

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2020

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2020

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2020

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2020

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2020

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2020

Collaborators (10)

Petr Broz

Full Professor

University of Lausanne

SWITZERLAND

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Rosalie Heilig

University of Glasgow

UNITED KINGDOM

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Fabienne Tacchini-Cottier

University of Lausanne

SWITZERLAND

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Zoe Day

Walter and Eliza Hall Institute of Medical Research

AUSTRALIA

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Enrico Radaelli

Associate Professor

University of Pennsylvania

UNITED STATES

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Jaclyn Pearson

MONASH UNIVERSITY

AUSTRALIA

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Ivan Poon

Laboratory Head/Associate Professor

La Trobe University

AUSTRALIA

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Roderick Lim

Associate Professor

University of Basel

SWITZERLAND

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Dave Boucher

Lecturer in Biomedical Science

University of York

UNITED KINGDOM

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Dominic De Nardo

MONASH UNIVERSITY

AUSTRALIA

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Kaiwen W Chen

Research Interests

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Articles (16)

A bacterial network of T3SS effectors counteracts host pro-inflammatory responses and cell death to promote infection

TBK1 and IKKε prevent premature cell death by limiting the activity of both RIPK1 and NLRP3 death pathways

Plasticity of cell death pathways ensures GSDMD activation during Yersinia pseudotuberculosis infection

Gasdermins as evolutionarily conserved executors of inflammation and cell death

Differential signalling requirements for RIPK1-dependent pyroptosis in neutrophils and macrophages

The small molecule raptinal can simultaneously induce apoptosis and inhibit PANX1 activity

RIPK1 and RIPK3 in antibacterial defence

Equally potent: Nlrp3 mutation in macrophages or neutrophils is sufficient to drive autoinflammation

Inflammasome and gasdermin signaling in neutrophils

RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signaling

Caspase-8–dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality

Cross talk between intracellular pathogens and cell death

Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria

Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD

Beyond inflammasomes: emerging function of gasdermins during apoptosis and NETosis

Pannexin‐1 promotes NLRP3 activation during apoptosis but is dispensable for canonical or noncanonical inflammasome activation

Collaborators (10)

Petr Broz

Rosalie Heilig

Fabienne Tacchini-Cottier

Zoe Day

Enrico Radaelli

Jaclyn Pearson

Ivan Poon

Roderick Lim

Dave Boucher

Dominic De Nardo

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