Kazuhiro Aoki

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教授/Professor

自然科学研究機構　生命創成探究センター/Exploratory Research Center on Life and Living Systems

Japan

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About

Professor Kazuhiro Aoki is a faculty member at the Exploratory Research Center on Life and Living Systems in Japan. His research focuses on cell cycle dynamics, biosensing technologies, and the biochemical interactions of signaling proteins. Recent publications include studies on cyclin-CDK dissociation constants, live-cell imaging techniques, and the activation of the p53 signaling pathway. Professor Aoki is dedicated to advancing the understanding of cellular processes through innovative experimental methodologies.

Recent Grants

Grant: Close

遺伝子にコードされたPhyB-PIF系による細胞・個体機能の光制御と新展開

Open Date: 2018-04-01

Close Date: 2020-03-31

Grant: Close

ERKシグナルによるG1-S期チェックポイントの閾値決定機構の定量的な理解

Open Date: 2018-04-01

Close Date: 2021-03-31

Grant: Close

癌細胞の脆弱性と頑強性の構成的理解

Open Date: 2016-07-19

Close Date: 2020-03-31

Grant: Close

Development of the light control technology of cellular function using PHYB-PIF system encoded by the gene

Open Date: 2016-04-01

Close Date: 2018-03-31

Grant: Close

Constitutive understanding of the three-dimensional morphogenesis control by ERK activity propagation

Open Date: 2016-04-01

Close Date: 2018-03-31

Articles (20)

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2022

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2021

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2021

Collaborators (22)

Koutarou D. Kimura

Professor

Nagoya University

JAPAN

Kazuhiro Aoki

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About

Recent Grants

Articles (20)

Quantification of cyclin–CDK dissociation constants using FCCS with green and near-infrared fluorescent proteins

Capturing CDKs in action: Live-cell biosensors pioneer the new frontiers in cell cycle research

Opto-p53: A light-controllable activation of p53 signaling pathway

Rapid and reversible dissolution of biomolecular condensates using light-controlled recruitment of a solubility tag

ORP9-PH domain-based fluorescent reporters for visualizing phosphatidylinositol 4-phosphate dynamics in living cells

Revisiting the evolution of bow-tie architecture in signaling networks

Cytoplasmic fluidization contributes to breaking spore dormancy in fission yeast

Live-cell imaging defines a threshold in CDK activity at the G2/M transition

γ-Secretase Cleaves Bifunctional Fatty Acid-Conjugated Small Molecules with Amide Bonds in Mammalian Cells

Molecular Design of FRET Probes Based on Domain Rearrangement of Protein Disulfide Isomerase for Monitoring Intracellular Redox Status

Optimal inference of molecular interaction dynamics in FRET microscopy

Optical Control of Cell Signaling with Red/Far-Red Light-Responsive Optogenetic Tools in Caenorhabditis elegans

Decoding cellular deformation from pseudo-simultaneously observed Rho GTPase activities

In vivo expression vector derived from anhydrobiotic tardigrade genome enables live imaging in Eutardigrada

Chemogenetic Manipulation of Endogenous Proteins in Fission Yeast Using a Self-Localizing Ligand-Induced Protein Translocation System

A chemogenetic platform for controlling plasma membrane signaling and synthetic signal oscillation

Quantitative live-cell imaging of GPCR downstream signaling dynamics

Redundant roles of EGFR ligands in the ERK activation waves during collective cell migration

Near-infrared imaging in fission yeast using a genetically encoded phycocyanobilin biosynthesis system

Optogenetic relaxation of actomyosin contractility uncovers mechanistic roles of cortical tension during cytokinesis

Collaborators (22)

Koutarou D. Kimura

Hironori Sugiyama

Yohei Kondo

Sae Tanaka

Shinya Tsukiji

Shinji Takada

Takayuki Uchihashi

Satoshi Sawai

Yusuke Mii

Kyoko Atsuta-Tsunoda

Yuhei Goto

Maho Yagi-Utsumi

Michiyuki Matsuda

Jared E. Toettcher

Tatsuyuki Yoshii

Koichi Kato

Keiko Kano

Kenta Terai

Emi Mishiro-Sato

Kazuharu Arakawa

Kei-ichi Okazaki

Nen Saito

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