Keisuke Shimada

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Assistant Professor

Osaka University

Japan

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About

Dr. Keisuke Shimada is an Assistant Professor at Osaka University, Japan. His research primarily focuses on male reproductive biology, particularly the molecular and genetic factors influencing sperm motility and fertility. Recent publications include studies on the roles of various genes and proteins in spermatogenesis and sperm head morphogenesis, utilizing advanced techniques such as proximity labeling and genome engineering.

Recent Grants

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Analysis of mitochondrial sheath formation mechanism using KO mouse

Open Date: 2020-04-01

Close Date: 2022-03-01

Grant: Close

Revealing the mechanism of mitochondrial localization in the sperm midpiece

Open Date: 2017-04-01

Close Date: 2020-03-01

Articles (24)

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2021

Collaborators (16)

Keizo Tokuhiro

Specially-Appointed Associate Professor

Kansai Medical University

JAPAN

Keisuke Shimada

Research Interests

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About

Recent Grants

Articles (24)

TEX38 localizes ZDHHC19 to the plasma membrane and regulates sperm head morphogenesis in mice

Mouse genome engineering uncovers 18 genes dispensable for male reproduction

Compensation for X-linked Pdha1 silencing by Pdha2 is essential for meiotic double-strand break repair in spermatogenesis

The absence of both RIBC1 and RIBC2 induces decreased sperm motility and litter size in male mice

Proximity labeling of axonemal protein CFAP91 identifies EFCAB5 that regulates sperm motility

FBXO24 deletion causes abnormal accumulation of membraneless electron-dense granules in sperm flagella and male infertility

MYCBPAP is a central apparatus protein required for centrosome–nuclear envelope docking and sperm tail biogenesis in mice

Development of functional spermatozoa in mammalian spermiogenesis

Gene-deficient mouse model established by CRISPR/Cas9 system reveals 15 reproductive organ-enriched genes dispensable for male fertility.

Individual disruption of 12 testis-enriched genes via the CRISPR/Cas9 system does not affect the fertility of male mice.

Affinity-tagged SMAD1 and SMAD5 mouse lines reveal transcriptional reprogramming mechanisms during early pregnancy

Multiple ageing effects on testicular/epididymal germ cells lead to decreased male fertility in mice

TSKS localizes to nuage in spermatids and regulates cytoplasmic elimination during spermiation

Testis‐specific proteins, TSNAXIP1 and 1700010I14RIK, are important for sperm motility and male fertility in mice

Evaluation of the efficacy of creatine chemical exchange saturation transfer imaging in assessing testicular maturity.

CCDC183 is essential for cytoplasmic invagination around the flagellum during spermiogenesis and male fertility

Disruption of testis-enriched cytochrome c oxidase subunit COX6B2 but not COX8C leads to subfertility.

Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis

IRGC1, a testis-enriched immunity related GTPase, is important for fibrous sheath integrity and sperm motility in mice

TULP2 deletion mice exhibit abnormal outer dense fiber structure and male infertility

LRRC23 is a conserved component of the radial spoke that is necessary for sperm motility and male fertility in mice

FAM209 associates with DPY19L2 and is required for sperm acrosome biogenesis and fertility in mice.

SPATA33 localizes calcineurin to the mitochondria and regulates sperm motility in mice

CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice.

Collaborators (16)

Keizo Tokuhiro

Taichi NODA

Takayuki Koyano

Haruhiko Miyata

Shimpei Kawamoto

Makoto Matsuyama

Yonggang Lu

kentaro shimada

Maki Kamoshita

Mikita Suyama

Hideyuki Shimizu

Tomoharu Yasuda

Yuhkoh Satouh

Diana Monsivais

Masahito Ikawa

Akinobu Matsumoto

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