Kenneth Margulies

Professor, Clinician-Educator

University of Pennsylvania

United States

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About

Dr. Kenneth Margulies is a Professor and Clinician-Educator at the University of Pennsylvania, United States. His research primarily focuses on hypertrophic cardiomyopathy, heart failure with preserved ejection fraction, and the role of myofibroblasts in cardiac tissue. He has published extensively on topics such as precision medicine, cardiac allograft rejection, and the mechanistic insights into myocardial structure and function in heart disease.

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2022

Collaborators (18)

Elise A. Corbin

UNITED STATES

Kenneth Margulies

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Articles (22)

Heterogeneous Dysregulation of Myosin Super-Relaxation and Energetics in Hypertrophic Cardiomyopathy

Precision Medicine Is in the Eye of the Beholder

Atrial Fibrillation in Patients Receiving Mavacamten for Obstructive Hypertrophic Cardiomyopathy

Pathophysiological insights into HFpEF from studies of human cardiac tissue

Myocardial ultrastructure of human heart failure with preserved ejection fraction

Nuclear ATP-citrate lyase regulates chromatin-dependent activation and maintenance of the myofibroblast gene program

Distinct cytoskeletal regulators of mechanical memory in cardiac fibroblasts and cardiomyocytes

Failing to Make the Grade: Conventional Cardiac Allograft Rejection Grading Criteria Are Inadequate for Predicting Rejection Severity

Truncated titin protein in dilated cardiomyopathy incorporates into the sarcomere and transmits force

Functional Impact of Alternative Metabolic Substrates in Failing Human Cardiomyocytes

Evaluation of Biologics ACE2/Ang(1–7) Encapsulated in Plant Cells for FDA Approval: Safety and Toxicology Studies

Noncanonical Form of ERAD Regulates Cardiac Hypertrophy

Biomechanical Impact of Pathogenic MYBPC3 Truncation Variant Revealed by Dynamically Tuning In Vitro Afterload

Tissue Rings PLOD Out a Second Hit in Becker Muscular Dystrophy

Myocardial Metabolomics of Human Heart Failure With Preserved Ejection Fraction

New Cardiotoxicity Risk Assessment Guidelines

Extracellular stiffness induces contractile dysfunction in adult cardiomyocytes via cell-autonomous and microtubule-dependent mechanisms.

Metabolomic Signatures of Myocardial Glucose Uptake on Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography

Metabolomic Profiling of the Effects of Dapagliflozin in Heart Failure With Reduced Ejection Fraction: DEFINE-HF

The Anemia Stress Index—Anemia, Transfusions, and Mortality in Patients with Continuous Flow Ventricular Assist Devices

Defects in the Proteome and Metabolome in Human Hypertrophic Cardiomyopathy

Computational Analysis of Routine Biopsies Improves Diagnosis and Prediction of Cardiac Allograft Vasculopathy

Collaborators (18)

Elise A. Corbin

Paco Bravo

Emily Flam

Mariam Meddeb

Senthil Selvaraj

Anant Madabhushi

Conchi Estaras

Mansoor Husain

Michael Previs

Pingfu Fu

Zoltan Arany

Benjamin Prosser

Eliot Peyster

Chris Glembotski

Alexia Vite

Barry Borlaug

Julien Ochala

Erik Blackwood

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