Julien Ochala

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Københavns Universitet

Denmark

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Recent Grants

Grant: Close

Defining the pivotal role of troponin T in muscle

Open Date: 2022-04-01

Close Date: 2024-03-01

Grant: Close

Unveiling the secrets of the enigmatic myosin binding protein C

Open Date: 2021-02-01

Close Date: 2024-01-01

Grant: Close

Understanding the mechanisms underlying myosinopathies

Open Date: 2019-09-15

Close Date: 2022-09-14

Grant: Close

Cellular and sub-cellular sampling using laser capture microdissection to understand disease mechanisms

Open Date: 2018-10-01

Close Date: 2023-09-30

Grant: Close

Phenotype variability in myosin-related congenital myopathies

Open Date: 2018-01-08

Close Date: 2022-01-07

Articles (19)

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2023

Collaborators (20)

Elisa Marie Crombie

University College London

UNITED KINGDOM

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Kenneth Margulies

Professor, Clinician-Educator

University of Pennsylvania

UNITED STATES

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Thibaux Van der Stede

Københavns Universitet

DENMARK

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Kenneth S. Campbell

UNITED STATES

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John Scott

Lab Head, Neurometabolism

Monash Institute of Pharmaceutical Sciences

AUSTRALIA

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Matthew John Stroud

King’s College London

UNITED KINGDOM

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Danial Ahwazi

Københavns Universitet

DENMARK

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Thomas Iskratsch

Professor

Queen Mary University of London

UNITED KINGDOM

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Atul Deshmukh

Københavns Universitet

DENMARK

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Jeffrey Brault

Associate Professor

Indiana University School of Medicine

UNITED STATES

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Stephen Harridge

Head of Centre / Professor

King’s College London

UNITED KINGDOM

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Glen Pyle

Professor and Assistant Chair

University of Guelph

CANADA

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Christopher Lewis

Københavns Universitet

DENMARK

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Ross Pollock

King’s College London

UNITED KINGDOM

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Alex Addinsall

Københavns Universitet

DENMARK

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Jeffrey Jenkin Kelu

King’s College London

UNITED KINGDOM

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Shih-Yin Tsai

National University of Singapore (NUS)

SINGAPORE

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Hannah Fox Dugdale

Lecturer in Molecular and Cellular Physiology

Loughborough University

UNITED KINGDOM

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Conchita Fraguas Bringas

Københavns Universitet

DENMARK

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Jon Oakhill

Australian Catholic University

AUSTRALIA

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Julien Ochala

Research Interests

Contact this professor

Recent Grants

Articles (19)

Human skeletal muscle fiber heterogeneity beyond myosin heavy chains

Integrated single‐cell functional‐proteomic profiling reveals a shift in myofibre specificity in human nemaline myopathy: A proof‐of‐principle study

Dysregulated skeletal muscle myosin super-relaxation and energetics in male participants with type 2 diabetes mellitus

Heterogeneous Dysregulation of Myosin Super-Relaxation and Energetics in Hypertrophic Cardiomyopathy

Pathogenic TNNT1 variants are associated with aberrant thin filament compliance and myofibre hyper-contractility

Increased cardiac myosin super-relaxation as an energy saving mechanism in hibernating grizzly bears

Site-specific quantification of the in vivo UFMylome reveals myosin modification in ALS

Muscle fibre size and myonuclear positioning in trained and aged humans

Aberrant myonuclear domains and impaired myofiber contractility despite marked hypertrophy in MYMK-related, Carey-Fineman-Ziter Syndrome

CaMKK2 is not involved in contraction-stimulated AMPK activation and glucose uptake in skeletal muscle

Myonuclear alterations associated with exercise are independent of age in humans

Predominant myosin superrelaxed state in canine myocardium with naturally occurring dilated cardiomyopathy

Revisiting specific force loss in human permeabilized single skeletal muscle fibers obtained from older individuals

Myosin Heavy Chain as a Novel Key Modulator of Striated Muscle Resting State

Slow myosin heavy chain 1 is required for slow myofibril and muscle fibre growth but not for myofibril initiation

Myosin post-translational modifications and function in the presence of myopathy-linked truncating MYH2 mutations

A rational approach to selective targeting of skeletal myosin

Activation of eIF4E-binding-protein-1 rescues mTORC1-induced sarcopenia by expanding lysosomal degradation capacity

Binding pocket dynamics along the recovery stroke of human β-cardiac myosin

Collaborators (20)

Elisa Marie Crombie

Kenneth Margulies

Thibaux Van der Stede

Kenneth S. Campbell

John Scott

Matthew John Stroud

Danial Ahwazi

Thomas Iskratsch

Atul Deshmukh

Jeffrey Brault

Stephen Harridge

Glen Pyle

Christopher Lewis

Ross Pollock

Alex Addinsall

Jeffrey Jenkin Kelu

Shih-Yin Tsai

Hannah Fox Dugdale

Conchita Fraguas Bringas

Jon Oakhill

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