Krystof Skach

University of Chemistry and Technology, Prague

Czech Republic

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Articles (7)

Year:

2025

Year:

2025

Year:

2024

Year:

2023

Year:

2023

Year:

2023

Year:

2020

Collaborators (4)

Vladimír Kryštof

Palacký University, Olomouc

CZECH REPUBLIC

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Vojtěch Duchoslav

Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry

CZECH REPUBLIC

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Thales Kronenberger

GERMANY

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Alžběta Dostálková

University of Chemistry and Technology

CZECH REPUBLIC

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Krystof Skach

Research Interests

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Articles (7)

Discovery of PXR Antagonist MI891 and PXR Degrader MI1013 and Their Roles in Hepatic Gene Regulation

The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model

Structure–activity relationship study of small-molecule inhibitor of Atg12-Atg3 protein–protein interaction

Inhibition of FLT3-ITD Kinase in Acute Myeloid Leukemia by New Imidazo[1,2-<i>b</i>]pyridazine Derivatives Identified by Scaffold Hopping

Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2-<i>a</i>]pyridine Structure.

Exploring positions 6 and 7 of a quinazoline-based scaffold leads to changes in selectivity and potency towards RIPK2/3 kinases

PF74 and Its Novel Derivatives Stabilize Hexameric Lattice of HIV-1 Mature-Like Particles.

Collaborators (4)

Vladimír Kryštof

Vojtěch Duchoslav

Thales Kronenberger

Alžběta Dostálková

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