Vladimír Kryštof

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Palacký University, Olomouc

Czech Republic

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Recent Grants

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Dual FLT3/CDK9 inhibition as a possible therapeutical approach for mixed lineage leukemia

Open Date: 2019-01-01

Close Date: 2021-12-31

Grant: Close

Pseudopeptide proteasome inhibitors

Open Date: 2018-01-01

Close Date: 2020-12-31

Grant: Close

Targeting BCR signalosome in B-cell malignancies

Open Date: 2017-01-04

Close Date: 2020-12-31

Grant: Close

New kinase inhibitors to treat acute myeloid leukemia

Open Date: 2015-01-05

Close Date: 2018-12-31

Grant: Close

Targeted Transport of Purine Cyclin-dependent Kinase Inhibitors into Cancer Cells

Open Date: 2015-01-01

Close Date: 2017-12-31

Articles (11)

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2023

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2023

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2023

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2023

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2022

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2022

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2022

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2022

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2022

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2021

Year:

2021

Collaborators (6)

Asta Žukauskaitė

CZECH REPUBLIC

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Jana Skerlova

Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry

CZECH REPUBLIC

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Richard Cmelik

Czech Academy of Sciences, Institute of Analytical Chemistry

CZECH REPUBLIC

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Petr Cankař

Palacký University

CZECH REPUBLIC

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Michal Rouchal

Tomas Bata University in Zlín

CZECH REPUBLIC

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Krystof Skach

University of Chemistry and Technology, Prague

CZECH REPUBLIC

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Vladimír Kryštof

Research Interests

Contact this professor

Recent Grants

Articles (11)

Inhibition of FLT3-ITD Kinase in Acute Myeloid Leukemia by New Imidazo[1,2-<i>b</i>]pyridazine Derivatives Identified by Scaffold Hopping

Design and synthesis of novel 1,2,4-triazolo[4,3-b]pyridazine derivatives with anti-cancer activity

Characterization of new highly selective pyrazolo[4,3-d]pyrimidine inhibitor of CDK7

A patent review of cyclin-dependent kinase 7 (CDK7) inhibitors (2018-2022)

Adamantane-Substituted Purine Nucleosides: Synthesis, Host–Guest Complexes with β-Cyclodextrin and Biological Activity

Synthesis and Structural Optimization of 2,7,9-Trisubstituted purin-8-ones as FLT3-ITD Inhibitors

Novel effective small-molecule inhibitors of protein kinases related to tau pathology in Alzheimer's disease

Design, Synthesis, In Silico Studies and Inhibitory Activity towards Bcr-Abl, BTK and FLT3-ITD of New 2,6,9-Trisubstituted Purine Derivatives as Potential Agents for the Treatment of Leukaemia

Synthesis of 4-styrylpyrazoles and Evaluation of their Inhibitory Effects on Cyclin-dependent Kinases

Adamantane-Substituted Purines and Their β-Cyclodextrin Complexes: Synthesis and Biological Activity

Synthesis and Antiproliferative Activity of 2,4,6,7-Tetrasubstituted-2H-pyrazolo[4,3-c]pyridines

Collaborators (6)

Asta Žukauskaitė

Jana Skerlova

Richard Cmelik

Petr Cankař

Michal Rouchal

Krystof Skach

Make your next move.

Vladimír Kryštof

Research Interests

Contact this professor

Recent Grants

Articles (11)

Inhibition of FLT3-ITD Kinase in Acute Myeloid Leukemia by New Imidazo[1,2-<i>b</i>]pyridazine Derivatives Identified by Scaffold Hopping

Design and synthesis of novel 1,2,4-triazolo[4,3-b]pyridazine derivatives with anti-cancer activity

Characterization of new highly selective pyrazolo[4,3-d]pyrimidine inhibitor of CDK7

A patent review of cyclin-dependent kinase 7 (CDK7) inhibitors (2018-2022)

Adamantane-Substituted Purine Nucleosides: Synthesis, Host–Guest Complexes with β-Cyclodextrin and Biological Activity

Synthesis and Structural Optimization of 2,7,9-Trisubstituted purin-8-ones as FLT3-ITD Inhibitors

Novel effective small-molecule inhibitors of protein kinases related to tau pathology in Alzheimer's disease

Design, Synthesis, In Silico Studies and Inhibitory Activity towards Bcr-Abl, BTK and FLT3-ITD of New 2,6,9-Trisubstituted Purine Derivatives as Potential Agents for the Treatment of Leukaemia

Synthesis of 4-styrylpyrazoles and Evaluation of their Inhibitory Effects on Cyclin-dependent Kinases

Adamantane-Substituted Purines and Their &beta;-Cyclodextrin Complexes: Synthesis and Biological Activity

Synthesis and Antiproliferative Activity of 2,4,6,7-Tetrasubstituted-2H-pyrazolo[4,3-c]pyridines

Collaborators (6)

Asta Žukauskaitė

Jana Skerlova

Richard Cmelik

Petr Cankař

Michal Rouchal

Krystof Skach

Make your next move.

Adamantane-Substituted Purines and Their β-Cyclodextrin Complexes: Synthesis and Biological Activity