Lars Plate

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Assistant Professor

Vanderbilt University

United States

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About

Dr. Lars Plate is an Assistant Professor at Vanderbilt University in the United States. His research focuses on advanced proteomics techniques and their applications in understanding diseases, particularly in relation to SARS-CoV-2 interactions, cystic fibrosis, and melanoma. Recent publications highlight his work on protein dynamics, drug response vulnerabilities, and the development of innovative sample preparation workflows.

Recent Grants

Grant: Close

Coordination of chaperone interactions that dictate protein folding and trafficking

Open Date: 2019-09-01

Close Date: 2024-06-30

Grant: Close

Selective Remodeling of the ER Proteostasis Network to Reduce Amyloid Light Chain Secretion for Myeloma Treatment

Open Date: 2015-07-01

Close Date: 2018-06-01

Articles (23)

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UNITED STATES

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Carlos Grijalva

Associate Professor

Vanderbilt University Medical Center

UNITED STATES

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Bjorn Knollmann

Professor

Vanderbilt University Medical Center

UNITED STATES

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David Samuels

Associate Professor

Vanderbilt University

UNITED STATES

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Lars Plate

Research Interests

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About

Recent Grants

Articles (23)

Proteomics as a complementary approach to measure norovirus infection in clinical samples

Time-Resolved Analysis of Protein–Protein Ensembles Using a Destabilizing Domain to Map Dynamic Interactions of SARS-CoV-2 nsp15

Dissecting Branch-Specific Unfolded Protein Response Activation in Drug-Tolerant BRAF-Mutant Melanoma Using Data-Independent Acquisition Mass Spectrometry

Development of an Adaptive, Economical, and Easy-to-Use SP3-TMT Automated Sample Preparation Workflow for Quantitative Proteomics

Proteostasis landscapes of cystic fibrosis variants reveal drug response vulnerability

Comparative Interactome Profiling of Nonstructural Protein 3 Across SARS-CoV-2 Variants Emerged During the COVID-19 Pandemic

Benchmarking AlphaMissense pathogenicity predictions against cystic fibrosis variants

Time-resolved interactome profiling deconvolutes secretory protein quality control dynamics

The proteostasis interactomes of trafficking-deficient variants of the voltage-gated potassium channel KV11.1 associated with long QT syndrome

Cystic Fibrosis Modulator Therapies: Bridging Insights from CF to other Membrane Protein Misfolding Diseases

Expression of SARS-CoV-2 Nonstructural Proteins 3 and 4 Can Tune the Unfolded Protein Response in Cell Culture

BRWD3 promotes KDM5 degradation to maintain H3K4 methylation levels

Elexacaftor/VX-445-mediated CFTR interactome remodeling reveals differential correction driven by mutation-specific translational dynamics

Site-specific crosslinking reveals Phosphofructokinase-L inhibition drives self-assembly and attenuation of protein interactions

CFTR Folding: From Structure and Proteostasis to Cystic Fibrosis Personalized Medicine

Compendium of proteins containing segments that exhibit <scp>zero‐tolerance</scp> to amino acid variation in humans

Distinct proteostasis states drive pharmacologic chaperone susceptibility for Cystic Fibrosis Transmembrane Conductance Regulator misfolding mutants.

Structural Comparative Modeling of Multi-Domain F508del CFTR

Mutation in protein disulfide isomerase A3 causes neurodevelopmental defects by disturbing endoplasmic reticulum proteostasis.

Apoptolidin family glycomacrolides target leukemia through inhibition of ATP synthase.

Small-molecule endoplasmic reticulum proteostasis regulator acts as a broad-spectrum inhibitor of dengue and Zika virus infections

Glycosylation limits forward trafficking of the tetraspan membrane protein PMP22

Thyroglobulin Interactome Profiling Defines Altered Proteostasis Topology Associated With Thyroid Dyshormonogenesis

Collaborators (8)

Kathryn Oliver

Jared Nordman

Brian Bachmann

Mary Lauren Benton

Charles R. Sanders

Carlos Grijalva

Bjorn Knollmann

David Samuels

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