Laurent O. Mosnier

Associate Professor

Scripps Research Institute

United States

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About

Laurent O. Mosnier is an Associate Professor at The Scripps Research Institute in the United States. His research focuses on the mechanisms of activated protein C and its therapeutic applications in thromboinflammation, coagulopathy, and macrophage inflammation. Recent publications include studies on the modulation of activated protein C functions and the development of engineered proteins aimed at improving hemostatic outcomes.

Articles (10)

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2025

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2024

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2024

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2023

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2022

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2021

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2020

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2020

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2020

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2020

Collaborators (1)

John Griffin

Adjunct Professor

University of California, San Diego

UNITED STATES

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Laurent O. Mosnier

Research Interests

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Articles (10)

Divergent modulation of activated protein C pleiotropic functions by antibodies that differ by a single amino acid

An orthosteric/allosteric bivalent peptide agonist comprising covalently linked protease-activated receptor-derived peptides mimics in vitro and in vivo activities of activated protein C

Biased agonism of protease-activated receptor-1 regulates thromboinflammation in murine sickle cell disease

Selective modulation of activated protein C activities by a nonactive site–targeting nanobody library

An engineered activated factor V for the prevention and treatment of acute traumatic coagulopathy and bleeding in mice

Activated protein C and PAR1‐derived and PAR3‐derived peptides are anti‐inflammatory by suppressing macrophage NLRP3 inflammasomes

An engineered factor Va prevents bleeding induced by direct-acting oral anticoagulants by different mechanisms

How much clotting is enough?

C‐terminal residues of activated protein C light chain contribute to its anticoagulant and cytoprotective activities

Role of thrombomodulin expression on hematopoietic stem cells

Collaborators (1)

John Griffin

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