Lewis Shi

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Associate Professor

The University of Alabama

United States

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About

Lewis Shi is an Associate Professor at The University of Alabama at Birmingham. His research areas include immunology, cancer biology, and the interplay between metabolic pathways and immune responses, as evidenced by his recent publications on T cell dynamics in chronic infection and cancer therapies. He has explored topics such as immune cell reprogramming, macrophage responses in tumor environments, and innovative treatment strategies in oncology.

Recent Grants

Grant: Close

Overcoming Tumor-Intrinsic Therapeutic Resistance to Immunotherapies

Open Date: 2021-12-01

Close Date: 2023-11-30

Grant: Close

Targeting metabolic checkpoints in the tumor microenvironment to boost efficacy of anti-CTLA-4

Open Date: 2019-04-01

Close Date: 2021-03-31

Grant: Close

Metabolic checkpoints in anti-CTLA-4 and anti-PD-1 immunotherapies

Open Date: 2018-11-01

Close Date: 2020-10-31

Articles (16)

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2025

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2025

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2025

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2024

Immune checkpoint blockers (ICBs) have brought great promise to patients with advanced melanoma, a tumor type that was claimed largely incurable not long ago. However, therapeutic resistance to ICBs has limited their utility in the clinic. Here, we provide a commentary on recent research endeavors concerning ICB resistance in melanoma patients.

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2023

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2022

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2022

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2022

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2021

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2020

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2020

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2020

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2020

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2020

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2020

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2020

Collaborators (7)

Fabio Candotti

Full Professor of Medicine

Lausanne University Hospital

SWITZERLAND

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Chandan Guha

Professor and Vice Chair

Montefiore Medical Center

UNITED STATES

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S M Mansour Haeryfar

Western University

CANADA

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Jianmei Leavenworth

Associate Professor

The University of Alabama

UNITED STATES

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Cai Grau

Aarhus University

DENMARK

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James A Bonner

UNITED STATES

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Brita Singers Sørensen

Aarhus University

DENMARK

View details

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Lewis Shi

Research Interests

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About

Recent Grants

Articles (16)

Gfi1 controls the formation of effector-like CD8<sup>+</sup> T cells during chronic infection and cancer.

PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy.

Requirements and Study Design for the Next Proton FLASH Clinical Trials: an International Multidisciplinary Delphi Consensus.

HIF1α-regulated glycolysis promotes activation-induced cell death and IFN-γ induction in hypoxic T cells.

HiJAKing Immunotherapy-Resistant Melanoma for a Cure

Editorial: Immune Cell Lineage Reprogramming in Cancer.

Selective suppression of melanoma lacking IFN-γ pathway by JAK inhibition depends on T cells and host TNF signaling.

B cell-T cell interplay in immune regulation: A focus on follicular regulatory T and regulatory B cell functions.

Bridging Radiotherapy to Immunotherapy: The IFN–JAK–STAT Axis

Metabolic vulnerabilities of intratumoral T cells and tumor cells

Lymph nodes: The cradle for antitumor immunity

Combining PARP and DNA-PK Inhibitors With Irradiation Inhibits HPV-Negative Head and Neck Cancer Squamous Carcinoma Growth

Sirt2: A master regulator of T cell metabolism?

Less is more for adoptive immunotherapy?

Glutamine: A bad guy for antitumor immunity?

Trimming the “fatty” intratumoral T regs for cancer immunotherapy

Collaborators (7)

Fabio Candotti

Chandan Guha

S M Mansour Haeryfar

Jianmei Leavenworth

Cai Grau

James A Bonner

Brita Singers Sørensen

Make your next move.

Lewis Shi

Research Interests

Explore related searches

Contact this professor

About

Recent Grants

Articles (16)

Gfi1 controls the formation of effector-like CD8&lt;sup&gt;+&lt;/sup&gt; T cells during chronic infection and cancer.

PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy.

Requirements and Study Design for the Next Proton FLASH Clinical Trials: an International Multidisciplinary Delphi Consensus.

HIF1α-regulated glycolysis promotes activation-induced cell death and IFN-γ induction in hypoxic T cells.

HiJAKing Immunotherapy-Resistant Melanoma for a Cure

Editorial: Immune Cell Lineage Reprogramming in Cancer.

Selective suppression of melanoma lacking IFN-γ pathway by JAK inhibition depends on T cells and host TNF signaling.

B cell-T cell interplay in immune regulation: A focus on follicular regulatory T and regulatory B cell functions.

Bridging Radiotherapy to Immunotherapy: The IFN–JAK–STAT Axis

Metabolic vulnerabilities of intratumoral T cells and tumor cells

Lymph nodes: The cradle for antitumor immunity

Combining PARP and DNA-PK Inhibitors With Irradiation Inhibits HPV-Negative Head and Neck Cancer Squamous Carcinoma Growth

Sirt2: A master regulator of T cell metabolism?

Less is more for adoptive immunotherapy?

Glutamine: A bad guy for antitumor immunity?

Trimming the “fatty” intratumoral T regs for cancer immunotherapy

Collaborators (7)

Fabio Candotti

Chandan Guha

S M Mansour Haeryfar

Jianmei Leavenworth

Cai Grau

James A Bonner

Brita Singers Sørensen

Make your next move.

Gfi1 controls the formation of effector-like CD8<sup>+</sup> T cells during chronic infection and cancer.