Lotfollahi

The Francis Crick Institute is recruiting a Postdoctoral Fellow for the Tissue Regeneration and Clonal Evolution (TRCE) Laboratory, led by Foad Rouhani. The four-year project is a computational investigation of how driver-mutation clones interact with their surrounding microenvironment in chronic liver disease and liver cancer. The researcher will develop and apply advanced artificial intelligence and machine-learning methods to large-scale spatial genomics, histology and multimodal biological datasets. The work will include graph neural networks, transformer models and generative AI approaches for studying clone–microenvironment interactions, together with integration of spatial transcriptomics, single-cell sequencing and imaging data. The project also involves clonal reconstruction and spatial mapping from genomic datasets, benchmarking strategies and reproducible computational workflows. The postdoctoral fellow will lead an independent project while collaborating with computational scientists, clinicians and experimental researchers across the Crick and the Wellcome Sanger Institute. The successful researcher will be embedded across both institutions and benefit from joint supervision, collaborative meetings, specialist datasets, computational infrastructure and expertise in generative AI, foundation models, spatial genomics, stem cell biology, tissue regeneration and cancer research. Prior genomics experience is not essential, as structured training and support will be provided.