Magdalene K. Montgomery

Fasting leads to many physiological changes in peripheral tissues, including the liver, where suppression of de novo lipogenesis through inhibition of sterol regulatory element‐binding protein 1 (SREBP‐1) expression and/or activity is a key adaptation to preserve glucose for maintenance of blood glucose levels. Yoshinori Takeuchi and colleagues provide novel mechanistic insights into the regulation of SREBP‐1 expression during fasting and highlight the importance of the hypothalamic–pituitary–adrenal axis and, particularly, glucocorticoid‐induced binding of the glucocorticoid receptor to enhancer regions of the KLF15 (Kruppel‐like factor 15) gene as a novel mechanism underlying the suppression of SREBP‐1 during fasting.

The present study examines the effects of exercise training on protein secretion from fast-twitch and slow-twitch muscle as well as visceral and subcutaneous adipose tissue of obese mice. Although exercise training leads to substantial remodeling of protein secretion from fast-twitch muscle, adipose tissue is completely refractory to exercise regulation.