Marc Normandin

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Associate Professor

Harvard Medical School

United States

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About

Marc Normandin is an Associate Professor at Harvard Medical School, located in the United States. His research focuses on advanced imaging techniques in neuroscience and oncology, exploring topics such as receptor occupancy in PET imaging, placebo response in depression, and the impact of radiopharmaceutical therapies in prostate cancer. Recent publications include investigations into mu-opioid receptor imaging and cardiac extracellular volume mapping, contributing to the understanding of complex neurodegenerative diseases and stress responses.

Recent Grants

Grant: Close

Quantitative receptor occupancy PET

Open Date: 2019-09-25

Close Date: 2021-07-31

Grant: Close

Center for Molecular Imaging Technology and Translation (CMITT)

Open Date: 2017-09-30

Close Date: 2022-06-30

Grant: Close

PEG-like Multimodal Nanoprobes for Imaging Enhanced Permeability Retention

Open Date: 2014-09-22

Close Date: 2019-05-31

Grant: Close

Gamma counter and continuous blood sampler for quantitative PET imaging

Open Date: 2014-07-01

Close Date: 2016-06-30

Grant: Close

Aberrant lipid metabolism in TSC diagnostics and therapeutics

Open Date: 2013-12-01

Close Date: 2016-03-31

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2021

Collaborators (5)

Daniel Dillon

Associate Professor

UNITED STATES

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Pedro Brugarolas

Assistant Professor

Massachusetts General Hospital

UNITED STATES

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Torben Pearson

University of Minnesota

UNITED STATES

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Wonil Lee

Yale University

UNITED STATES

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Heidi Jacobs

Associate Professor of Radiology

Massachusetts General Hospital

UNITED STATES

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Marc Normandin

Research Interests

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About

Recent Grants

Articles (20)

Selective Mu-Opioid Receptor Imaging Using <sup>18</sup>F-Labeled Carfentanils

Free‐breathing 3D cardiac extracellular volume (ECV) mapping using a linear tangent space alignment (LTSA) model

PET Mapping of Receptor Occupancy Using Joint Direct Parametric Reconstruction

PET Mapping of Receptor Occupancy Using Joint Direct Parametric Reconstruction.

Novel multi-modal methodology to investigate placebo response in major depressive disorder

Deciphering the effects of radiopharmaceutical therapy in the tumor microenvironment of prostate cancer: an in-silico exploration with spatial transcriptomics.

Acute Stress Increases Striatal Connectivity With Cortical Regions Enriched for μ and κ Opioid Receptors

Head-to-head comparison of [<sup>18</sup>F]-Flortaucipir, [<sup>18</sup>F]-MK-6240 and [<sup>18</sup>F]-PI-2620 postmortem binding across the spectrum of neurodegenerative diseases

PET imaging of M4 muscarinic acetylcholine receptors in rhesus macaques using [<sup>11</sup>C]MK-6884: Quantification with kinetic modeling and receptor occupancy by CVL-231 (emraclidine), a novel positive allosteric modulator

PET imaging of M4 muscarinic acetylcholine receptors in rhesus macaques using [<sup>11</sup>C]MK-6884: Quantification with kinetic modeling and receptor occupancy by CVL-231 (emraclidine), a novel positive allosteric modulator.

A multi-pronged investigation of option generation using depression, PET and modafinil

Impact of 40 Hz Transcranial Alternating Current Stimulation on Cerebral Tau Burden in Patients with Alzheimer's Disease: A Case Series.

Impact of 40 Hz Transcranial Alternating Current Stimulation on Cerebral Tau Burden in Patients with Alzheimer's Disease: A Case Series

Synthesis and Characterization of 5-(2-Fluoro-4-[<sup>11</sup>C]methoxyphenyl)-2,2-dimethyl-3,4-dihydro-2<i>H</i>-pyrano[2,3-<i>b</i>]pyridine-7-carboxamide as a PET Imaging Ligand for Metabotropic Glutamate Receptor 2.

In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer’s disease pathology and cognitive decline

Radiochemical Synthesis and Evaluation in Non-Human Primates of 3-[11C]methoxy-4-aminopyridine: A Novel PET Tracer for Imaging Potassium Channels in the CNS

Near-Infrared Fluorescence Imaging of Carotid Plaques in an Atherosclerotic Murine Model

In vivo imaging of mGlu5 receptor expression in humans with Fragile X Syndrome towards development of a potential biomarker.

Neurovascular imaging with QUTE-CE MRI in APOE4 rats reveals early vascular abnormalities.

Quantification of Myocardial Mitochondrial Membrane Potential Using PET.

Collaborators (5)

Daniel Dillon

Pedro Brugarolas

Torben Pearson

Wonil Lee

Heidi Jacobs

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