Marcin Ratajewski

Head, Associate Professor

Poland

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About

Marcin Ratajewski is the Head and Associate Professor at the Institute of Medical Biology PAS in Poland. His research areas include AI-driven drug design, epigenetic regulation, and the role of RORγT in immune modulation and cancer therapy, as evidenced by his recent publications. He has explored novel ligands for RORγ/RORγT receptors and the impact of Staphylococcus aureus on DNA methylation in immune cells.

Articles (20)

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2025

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2020

Collaborators (4)

Marta Sobalska-Kwapis

University of Łódź

POLAND

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Małgorzata Zakłos-Szyda

University Professor

Lodz University of Technology

POLAND

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Grażyna Budryn

Lodz University of Technology

POLAND

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Kaja Karaś

Institute of Medical Biology Polish Academy of Sciences

POLAND

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Marcin Ratajewski

Research Interests

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Articles (20)

Identification of a Novel Indolizine RORγT Inverse Agonist Using the AI-Driven Drug Design Platform

Staphylococcus aureus α-hemolysin induces DNA methylation changes in human Th1 cells.

The cyclin-dependent kinase inhibitor AT7519 is a human RORγt agonist.

Epigenetic regulation of the human GDAP1 gene

α-Hemolysin from Staphylococcus aureus Changes the Epigenetic Landscape of Th17 Cells

Evaluation of the activity of cardiac glycosides on RORγ and RORγT nuclear receptors

QSPRmodeler - An open source application for molecular predictive analytics.

Anti-hepatocellular carcinoma activity of the cyclin-dependent kinase inhibitor AT7519

Trichostatin A inhibits expression of the human SLC2A5 gene via SNAI1/SNAI2 transcription factors and sensitizes colon cancer cells to platinum compounds

RORγT agonists as immune modulators in anticancer therapy.

The application of machine learning methods to the prediction of novel ligands for ROR<i>γ</i>/ROR<i>γ</i>T receptors.

Chlorpromazine, a Clinically Approved Drug, Inhibits SARS-CoV-2 Nucleocapsid-Mediated Induction of IL-6 in Human Monocytes

Identification of Corosolic and Oleanolic Acids as Molecules Antagonizing the Human RORγT Nuclear Receptor Using the Calculated Fingerprints of the Molecular Similarity

Targeting EGFR in melanoma - The sea of possibilities to overcome drug resistance.

Phenolics-Rich Extracts of Dietary Plants as Regulators of Fructose Uptake in Caco-2 Cells via GLUT5 Involvement

Targeting SIRT2 Sensitizes Melanoma Cells to Cisplatin via an EGFR-Dependent Mechanism

Nucleocapsid and Spike Proteins of the Coronavirus SARS-CoV-2 Induce <i>IL6</i> in Monocytes and Macrophages—Potential Implications for Cytokine Storm Syndrome

Hypoxia regulates human mast cell adhesion to fibronectin via the PI3K/AKT signaling pathway.

SARS-CoV-2 Proteins Induce IFNG in Th1 Lymphocytes Generated from CD4+ Cells from Healthy, Unexposed Polish Donors

Anticancer Imidazoacridinone C-1311 is Effective in Androgen-Dependent and Androgen-Independent Prostate Cancer Cells

Collaborators (4)

Marta Sobalska-Kwapis

Małgorzata Zakłos-Szyda

Grażyna Budryn

Kaja Karaś

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