Marek Ostaszewski

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Luxembourg

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Recent Grants

Grant: Close

Beyond COVID (Task lead)

Open Date: 2021-10-01

Close Date: 2024-09-01

Grant: Close

ImmUniverse: Transforming Diagnosis and Therapy of Immune-Mediated Diseases (Task lead)

Open Date: 2020-01-01

Close Date: 2025-01-01

Grant: Close

Biomarkers in Atopic Dermatitis and Psoriasis (Task lead)

Open Date: 2019-04-01

Close Date: 2024-03-01

Grant: Close

A Systems medicine approach to chronic inflammatory disease (Task lead)

Open Date: 2017-01-01

Close Date: 2022-09-01

Articles (11)

Exploration and comparison of molecular mechanisms across diseases using <scp>MINERVA</scp> Net

Protein function is often interpreted using molecular interaction diagrams, encoding roles a given protein plays in various molecular mechanisms. Information about disease‐related mechanisms can be inferred from disease maps, knowledge repositories containing manually constructed systems biology diagrams. Disease maps hosted on the Molecular Interaction Network VisuAlization (MINERVA) Platform are individually accessible through a REST API interface of each instance, making it challenging to systematically explore their contents. To address this challenge, we introduce the MINERVA Net web service, a repository of open‐access disease maps allowing users to publicly share minimal information about their maps. The MINERVA Net repository provides REST API endpoints of particular disease maps, which then can be individually queried for content. In this article, we describe the concept of MINERVA Net and illustrate its use by comparing proteins and their interactions in three different disease maps.

Year:

2023

Collaborators (18)

Nick Dand

King’s College London

UNITED KINGDOM

Robert Phair

Co-founder and Chief Science Officer

-

UNITED STATES

Anna Niarakis

Full Professor

Université Toulouse III - Paul Sabatier

FRANCE

David Marshall

University of York

UNITED KINGDOM

Clare Mackay

University of Oxford

UNITED KINGDOM

Enrico Glaab

-

LUXEMBOURG

Paola Di Meglio

King’s College London

UNITED KINGDOM

Jan Hasenauer

Professor

Rheinische Friedrich-Wilhelms-Universität Bonn

GERMANY

Marc Gillespie

Professor

St. John's University

UNITED STATES

Felix Bruno Kleine Borgmann

-

GERMANY

Kenneth G. C. Smith

University of Cambridge

UNITED KINGDOM

Rudi Balling

Senior Professor

University of Bonn

GERMANY

Susan Coort

University of Maastricht

NETHERLANDS

ravi ramessur

King’s College London

UNITED KINGDOM

Manuel Buttini

-

LUXEMBOURG

Tobias Czauderna

Professor

Hochschule Mittweida

GERMANY

Ralf Stephan

Institute for Globally Distributed Open Research and Education

SWEDEN

Marvin Martens

University of Maastricht

NETHERLANDS
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