Maria José Umbelino Ferreira

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Faculty of Pharmacy, University of Lisbon

Portugal

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Exploiting monoterpene indole alkaloid derivatives for overcoming resistance in BRCA-deficient cancers. In silico characterization of binding modes-Exploiting monoterpene indole alkaloid derivatives for overcoming resistance in BRCA-deficient cancers. In silico characterization of binding modes

Open Date: 2023-03-01

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Exploiting monoterpene indole alkaloid derivatives for overcoming resistance in BRCA-deficient cancers. In silico characterization of binding modes

Open Date: 2023-01-01

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Targeting multidrug resistance in cancer by plant-derived indole alkaloids and derivatives

Open Date: 2020-12-01

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Targeting multidrug resistance in cancer by plant-derived indole alkaloids and derivatives

Open Date: 2020-12-01

Close Date:

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Plant-derived compounds as anticancer agents: a promising approach for overcoming multidrug resistance-FCT/NKFIH, 2019/2020

Open Date: 2019-01-01

Close Date: 2020-01-01

Articles (17)

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2021

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2021

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2021

Collaborators (10)

Gabriella Spengler

assistant professor

Szent-Györgyi Albert Medical School, University of Szeged

HUNGARY

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Francisco Estévez

Professor of Biochemistry and Molecular Biology

Universidad de Las Palmas de Gran Canaria

SPAIN

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Maria Natália Dias Soeiro Cordeiro

Associate Professor

Universidade do Porto Faculdade de Engenharia

PORTUGAL

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Noélia Duarte

Assistant Professor

Faculty of Pharmacy, University of Lisbon

PORTUGAL

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Joao Aires-de-Sousa

Universidade Nova de Lisboa

PORTUGAL

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Cátia Ramalhete

Universidade Atlântica

PORTUGAL

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Daniel J. V. A. dos Santos

PORTUGAL

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Lucília Saraiva

Assistant Professor

Universidade do Porto Faculdade de Medicina

PORTUGAL

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Jitka Viktorova

University of Chemistry and Technology

CZECH REPUBLIC

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Emília Sousa

University of Porto

PORTUGAL

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Maria José Umbelino Ferreira

Research Interests

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Contact this professor

Recent Grants

Articles (17)

Monoterpene indole alkaloids with anticancer activity from Tabernaemontana species

Lycorine and homolycorine derivatives for chemo-sensitizing resistant human ovarian adenocarcinoma cells

Nitrogen-containing andrographolide derivatives with multidrug resistance reversal effects in cancer cells

Nitrogen-containing andrographolide derivatives with multidrug resistance reversal effects in cancer cells

Long-range communication between transmembrane- and nucleotide-binding domains does not depend on drug binding to mutant P-glycoprotein

Lycorine Carbamate Derivatives for Reversing P-glycoprotein-Mediated Multidrug Resistance in Human Colon Adenocarcinoma Cells

Probing the Allosteric Modulation of P-Glycoprotein: A Medicinal Chemistry Approach Toward the Identification of Noncompetitive P-Gp Inhibitors

Natural Product-Derived Compounds for Targeting Multidrug Resistance in Cancer and Microorganisms

Reversal of P-glycoprotein-mediated multidrug resistance by natural N-alkylated indole alkaloid derivatives in KB-ChR-8-5 drug-resistant cancer cells

Momordica balsamina: phytochemistry and pharmacological potential of a gifted species

Amaryllidaceae-Type Alkaloids from Pancratium maritimum: Apoptosis-Inducing Effect and Cell Cycle Arrest on Triple-Negative Breast Cancer Cells

Alkaloids in Future Drug Discovery

Editorial: “Natural Products as a Tool to Design New anti-MDR Lead Molecules.”

Alkylated monoterpene indole alkaloid derivatives as potent P-glycoprotein inhibitors in resistant cancer cells

BBIT20 inhibits homologous DNA repair with disruption of the BRCA1–BARD1 interaction in breast and ovarian cancer

Correction to: Natural products in drug discovery and human health (Phytochemistry Reviews, (2021), 20, 1, (1-4), 10.1007/s11101-020-09736-y)

Exploring the monoterpene indole alkaloid scaffold for reversing p-glycoprotein-mediated multidrug resistance in cancer

Collaborators (10)

Gabriella Spengler

Francisco Estévez

Maria Natália Dias Soeiro Cordeiro

Noélia Duarte

Joao Aires-de-Sousa

Cátia Ramalhete

Daniel J. V. A. dos Santos

Lucília Saraiva

Jitka Viktorova

Emília Sousa

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