Lucília Saraiva

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Assistant Professor

Universidade do Porto Faculdade de Medicina

Portugal

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About

Lucília Saraiva is an Assistant Professor at the Universidade do Porto Faculdade de Farmácia in Portugal. Her research focuses on nanotechnology for cancer treatment, mechanisms of p53-targeting molecules, and the exploration of anticancer compounds and their effects. She has contributed to various articles on topics including melanoma treatment, DNA repair in pancreatic cancer, and neuroprotective agents.

Recent Grants

Grant: Close

Beat Therapeutics

Open Date: 2023-01-01

Close Date: 2025-01-01

Grant: Close

Beat Therapeutics

Open Date: 2023-01-01

Close Date: 2024-01-01

Grant: Close

Exploiting monoterpene indole alkaloid derivatives for overcoming resistance in BRCA-deficient cancers. In silico characterization of binding modes - 2022.05718.PTDC

Open Date: 2023-01-01

Close Date: 2024-01-01

Grant: Close

BBIT20

Open Date: 2021-01-01

Close Date: 2021-01-01

Grant: Close

BBIT20: An inhibitor of homologous recombination

Open Date: 2021-01-01

Close Date: 2022-01-01

Articles (22)

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Collaborators (22)

Paulo Correia-de-Sá

University of Porto

PORTUGAL

Lucília Saraiva

Research Interests

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About

Recent Grants

Articles (22)

Mechanistic Insights of a p53-Targeting Small Molecule

Promising Nanotechnology-Based Strategies for Melanoma Treatment

Design and Synthesis of Boronic Chalcones with Dual Anticancer and Anti-Inflammatory Activity

Exploring the Anticancer Properties of 1,2,3-Triazole-Substituted Andrographolide Derivatives

A first-in-class inhibitor of homologous recombination DNA repair counteracts tumour growth, metastasis and therapeutic resistance in pancreatic cancer

Chiral hydroxymethyl-1H,3H-pyrrolo[1,2-c]thiazoles: the search for selective p53-activating agents for colorectal cancer therapy

BP-M345 as a Basis for the Discovery of New Diarylpentanoids with Promising Antimitotic Activity

P53 and the Ultraviolet Radiation-Induced Skin Response: Finding the Light in the Darkness of Triggered Carcinogenesis

3-Tetrazolyl-ß-carboline derivatives as potential neuroprotective agents

Extraction optimization and reactivity of 7α-acetoxy-6β-hydroxyroyleanone and ability of its derivatives to modulate PKC isoforms

Discovery of a New Chalcone-Trimethoxycinnamide Hybrid with Antimitotic Effect: Design, Synthesis, and Structure—Activity Relationship Studies

Metabolism-Guided Optimization of Tryptophanol-Derived Isoindolinone p53 Activators

Counteracting Colon Cancer by Inhibiting Mitochondrial Respiration and Glycolysis with a Selective PKCδ Activator

Overcoming therapeutic resistance in pancreatic cancer: Emerging opportunities by targeting BRCAs and p53

Structure–Activity Relationship Studies of Chalcones and Diarylpentanoids with Antitumor Activity: Potency and Selectivity Optimization

Antitumor Activity of the Xanthonoside XGAc in Triple-Negative Breast, Ovarian and Pancreatic Cancer by Inhibiting DNA Repair

Bioactive Diarylpentanoids: Insights into the Biological Effects beyond Antitumor Activity and Structure–Activity Relationships

Celosia trigyna Linn (Cucurbitaceae) Annihilate Human Breast, Colon, and Lung Cancer Cells: Combination of Cheap Template for Anticancer Screening

3-(1,2,3-Triazol-4-yl)-β-Carbolines and 3-(1H-Tetrazol-5-yl)-β-Carbolines: Synthesis and Evaluation as Anticancer Agents

Amaryllidaceae-Type Alkaloids from Pancratium maritimum: Apoptosis-Inducing Effect and Cell Cycle Arrest on Triple-Negative Breast Cancer Cells

Deciphering the Role of p53 and TAp73 in Neuroblastoma: From Pathogenesis to Treatment

Folic acid-mesoporous silicon nanoparticles enhance the anticancer activity of the p73-activating small molecule LEM2

Collaborators (22)

Paulo Correia-de-Sá

Paulo Jorge Cardoso da Costa

Sara Ricardo

Maria Santos

Patrícia Dias de Mendonça Rijo

Maria Helena Amaral

Maria Adelina Coelho Costa

Vera Isca

Marco G Alves

Joana Moreira

Hassan Bousbaa

Teresa Pinho e Melo

Patrícia Silva

Vilma A. Sardão

Andreia Palmeira

Catarina Roma-Rodrigues

Maria José Umbelino Ferreira

Alexandra Antunes

Maria Soares

Paula Leandro

Honorina CIdade

Alexandra Fernandes

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