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Maria Novella ROMANELLI

University of Florence

Italy

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Research Interests

Pharmacology

100%

Pharmaceutical Chemistry

80%

Drug Formulation

40%

Cytochrome P450

40%

Alkaloid Chemistry

40%

Drug Repurposing

30%

Neuropharmacology

30%

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Articles13

Dual Inhibitors of P-gp and Carbonic Anhydrase XII (hCA XII) against Tumor Multidrug Resistance with Piperazine Scaffold

Article Link

Year:

2024

The novel non-hallucinogenic compound DM506 (3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole) induces sedative- and anxiolytic-like activity in mice by a mechanism involving 5-HT2A receptor activation

Article Link

Year:

2024

DM506 (3-Methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole fumarate), a Novel Derivative of Ibogamine, Inhibits α7 and α9α10 Nicotinic Acetylcholine Receptors by Different Allosteric Mechanisms

Article Link

Year:

2023

Recent Advances in the Discovery of Nicotinic Acetylcholine Receptor Allosteric Modulators

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Year:

2023

Synthetic Approaches to Piperazine-Containing Drugs Approved by FDA in the Period of 2011–2023

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Year:

2023

The Tetrahydroisoquinoline Scaffold in ABC Transporter Inhibitors that Act as Multidrug Resistance (MDR) Reversers

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Year:

2022

New Dual P-Glycoprotein (P-gp) and Human Carbonic Anhydrase XII (hCA XII) Inhibitors as Multidrug Resistance (MDR) Reversers in Cancer Cells

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Year:

2022

The piperazine scaffold for novel drug discovery efforts: the evidence to date

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Year:

2022

Overcoming Multidrug Resistance (MDR): Design, Biological Evaluation and Molecular Modelling Studies of 2,4‐Substituted Quinazoline Derivatives

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Year:

2022

New Histamine-Related Five-Membered N-Heterocycle Derivatives as Carbonic Anhydrase I Activators

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Year:

2022

The HCN channel as a pharmacological target: Why, where, and how to block it

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Year:

2021

Dual BET/HDAC inhibition to relieve neuropathic pain: Recent advances, perspectives, and future opportunities

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Year:

2021

Carbonic Anhydrase IV Selective Inhibitors Counteract the Development of Colitis-Associated Visceral Pain in Rats

Article Link

Year:

2021

Collaborators11

Elisabetta Cerbai

Professor

Università degli Studi di Napoli Federico II

ITALY

Chiara Riganti

tenured assistant professor

University of Turin

ITALY

Alessandra Pacini

University of Florence

ITALY

Alessio Nocentini

University of Florence

ITALY

Astrid Parenti

Assistant Professor

University of Florence

ITALY

David John Adams

Distinguished Professor

University of Wollongong

AUSTRALIA

Valentina Balducci

ITALY

Elisabetta Teodori

University of Florence

ITALY

ALICAN GULSEVIN

Assistant Professor

Butler University

UNITED STATES

Gianluca Bartolucci

University of Florence

ITALY

Silvia Dei

University of Florence

ITALY

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